GR1000618B - Method for the hiv suppression by using nucleosidic associations derivatives - Google Patents
Method for the hiv suppression by using nucleosidic associations derivativesInfo
- Publication number
- GR1000618B GR1000618B GR900100189A GR900100189A GR1000618B GR 1000618 B GR1000618 B GR 1000618B GR 900100189 A GR900100189 A GR 900100189A GR 900100189 A GR900100189 A GR 900100189A GR 1000618 B GR1000618 B GR 1000618B
- Authority
- GR
- Greece
- Prior art keywords
- derivatives
- nucleosidic
- associations
- hiv
- hiv suppression
- Prior art date
Links
- 230000001629 suppression Effects 0.000 title 1
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 2
- BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 229960002656 didanosine Drugs 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 239000002718 pyrimidine nucleoside Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 239000011885 synergistic combination Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται στη χρήση συνεργητικών συνδυασμών παραγώγων νουκλεοζίτη προς αναστολή της αντιγραφής ιού ανοσοανεπάρκειας ανθρώπου (HIV) περιορίζοντας κατά τον τρόπο αυτό τη μόλυνση HIV. Σε μια συγκεκριμένη πρακτική εφαρμογή το ανάλογο νουκλεοζίτη οπουρίνης, διδεοξυινοζίνη, συνδυασμένο με το ανάλογο νουκλεοζίτη πυριμιδίνης, 2,3- διδεοξυ-2,3-διδεϋδροθυμιδίνη 1 (d4T), παρουσιάζουν ισχυρή συνεργητική ενεργότητα και μειωμένη κυτταροτοξική ενεργότητα έναντι κυττάρων θηλαστικών. ωThe present invention relates to the use of synergistic combinations of nucleoside derivatives to inhibit human immunodeficiency virus (HIV) replication thereby limiting HIV infection. In a particular practical embodiment, the opurine nucleoside analog, dideoxyinosine, in combination with the pyrimidine nucleoside analog, 2,3-dideoxy-2,3-dihydrothymidine 1 (d4T), exhibits potent synergistic activity and reduced cytotoxic activity. ω
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32493489A | 1989-03-17 | 1989-03-17 | |
US40190889A | 1989-09-01 | 1989-09-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
GR900100189A GR900100189A (en) | 1990-07-31 |
GR1000618B true GR1000618B (en) | 1992-08-31 |
Family
ID=26984692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR900100189A GR1000618B (en) | 1989-03-17 | 1990-03-14 | Method for the hiv suppression by using nucleosidic associations derivatives |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0464137A4 (en) |
JP (1) | JPH04504850A (en) |
KR (1) | KR920700653A (en) |
CN (1) | CN1045791A (en) |
AU (1) | AU5351490A (en) |
CA (1) | CA2050473A1 (en) |
DD (1) | DD301787A9 (en) |
FI (1) | FI914367A0 (en) |
GR (1) | GR1000618B (en) |
HU (1) | HU208254B (en) |
IL (1) | IL93783A0 (en) |
NO (1) | NO913659L (en) |
NZ (1) | NZ232912A (en) |
OA (1) | OA09555A (en) |
PL (1) | PL284343A1 (en) |
PT (1) | PT93449A (en) |
WO (1) | WO1990011081A1 (en) |
YU (1) | YU53790A (en) |
ZW (1) | ZW3290A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ285232B6 (en) * | 1991-05-16 | 1999-06-16 | Glaxo Group Limited | Antiviral mixtures and pharmaceutical preparation containing thereof |
AU4716299A (en) * | 1998-06-24 | 2000-01-10 | Emory University | Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv |
WO2002074910A2 (en) | 2001-03-15 | 2002-09-26 | Trustees Of Boston College, The | Selective anti-viral nucleoside chain terminators |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987001284A1 (en) * | 1985-08-26 | 1987-03-12 | United States Of America, Represented By The Unite | Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine |
GB8712115D0 (en) * | 1987-05-22 | 1987-06-24 | Hoffmann La Roche | Pyrimidine derivatives |
US4837311A (en) * | 1987-06-22 | 1989-06-06 | Hoffman-La Roche Inc. | Anti-retroviral compounds |
NZ226672A (en) * | 1987-10-30 | 1991-07-26 | Hoffmann La Roche | 6-amino-9-(2,3-dideoxy-2-fluoro-b-d-threopentofuranosyl)-9h-purine derivatives and pharmaceutical compositions |
US4908440A (en) * | 1987-11-12 | 1990-03-13 | Bristol Myers Company | 2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides |
-
1990
- 1990-03-14 GR GR900100189A patent/GR1000618B/en unknown
- 1990-03-14 NZ NZ232912A patent/NZ232912A/en unknown
- 1990-03-15 PT PT93449A patent/PT93449A/en not_active Application Discontinuation
- 1990-03-16 AU AU53514/90A patent/AU5351490A/en not_active Abandoned
- 1990-03-16 HU HU902898A patent/HU208254B/en not_active IP Right Cessation
- 1990-03-16 CA CA002050473A patent/CA2050473A1/en not_active Abandoned
- 1990-03-16 EP EP19900905787 patent/EP0464137A4/en not_active Withdrawn
- 1990-03-16 JP JP2505494A patent/JPH04504850A/en active Pending
- 1990-03-16 PL PL28434390A patent/PL284343A1/en unknown
- 1990-03-16 KR KR1019910701134A patent/KR920700653A/en not_active Application Discontinuation
- 1990-03-16 WO PCT/US1990/001424 patent/WO1990011081A1/en not_active Application Discontinuation
- 1990-03-16 ZW ZW32/90A patent/ZW3290A1/en unknown
- 1990-03-16 DD DD90338833A patent/DD301787A9/en unknown
- 1990-03-17 CN CN90102298A patent/CN1045791A/en active Pending
- 1990-03-18 IL IL93783A patent/IL93783A0/en unknown
- 1990-03-19 YU YU53790A patent/YU53790A/en unknown
-
1991
- 1991-09-17 NO NO91913659A patent/NO913659L/en unknown
- 1991-09-17 FI FI914367A patent/FI914367A0/en not_active Application Discontinuation
- 1991-09-17 OA OA60072A patent/OA09555A/en unknown
Also Published As
Publication number | Publication date |
---|---|
HU208254B (en) | 1993-09-28 |
DD301787A9 (en) | 1994-01-13 |
FI914367A0 (en) | 1991-09-17 |
PL284343A1 (en) | 1991-06-03 |
AU5351490A (en) | 1990-10-22 |
EP0464137A1 (en) | 1992-01-08 |
HU902898D0 (en) | 1991-12-30 |
NO913659L (en) | 1991-10-18 |
HUT57988A (en) | 1992-01-28 |
CN1045791A (en) | 1990-10-03 |
KR920700653A (en) | 1992-08-10 |
WO1990011081A1 (en) | 1990-10-04 |
EP0464137A4 (en) | 1992-01-15 |
IL93783A0 (en) | 1990-12-23 |
GR900100189A (en) | 1990-07-31 |
NO913659D0 (en) | 1991-09-17 |
OA09555A (en) | 1993-01-31 |
NZ232912A (en) | 1992-06-25 |
CA2050473A1 (en) | 1990-09-18 |
YU53790A (en) | 1993-05-28 |
JPH04504850A (en) | 1992-08-27 |
ZW3290A1 (en) | 1990-11-07 |
PT93449A (en) | 1990-11-07 |
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