GEP20115350B - Ophthalmological gel and a method for the use thereof - Google Patents
Ophthalmological gel and a method for the use thereofInfo
- Publication number
- GEP20115350B GEP20115350B GEAP200811585A GEAP2008011585A GEP20115350B GE P20115350 B GEP20115350 B GE P20115350B GE AP200811585 A GEAP200811585 A GE AP200811585A GE AP2008011585 A GEAP2008011585 A GE AP2008011585A GE P20115350 B GEP20115350 B GE P20115350B
- Authority
- GE
- Georgia
- Prior art keywords
- gel
- value
- sodium hydroxide
- hydroxide solution
- solution
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 9
- 239000000243 solution Substances 0.000 abstract 4
- JLKVZOMORMUTDG-UHFFFAOYSA-N 1-(2-hydroxyethyl)-4,6-dimethylpyrimidin-2-one Chemical compound CC=1C=C(C)N(CCO)C(=O)N=1 JLKVZOMORMUTDG-UHFFFAOYSA-N 0.000 abstract 2
- 229920002125 Sokalan® Polymers 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000012907 medicinal substance Substances 0.000 abstract 2
- 239000004584 polyacrylic acid Substances 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 239000003755 preservative agent Substances 0.000 abstract 2
- 239000003381 stabilizer Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- RDEIXVOBVLKYNT-HDZPSJEVSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-[(1r)-1-aminoethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2 Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)[C@@H](C)N)N)[C@@H](N)C[C@H]1N.O1[C@H]([C@@H](C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-HDZPSJEVSA-N 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- 238000013019 agitation Methods 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 239000012984 antibiotic solution Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229960000686 benzalkonium chloride Drugs 0.000 abstract 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940009662 edetate Drugs 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Colloid Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to medicine. The inventive concerns the new ophthalmological gel and method for its production. The ophtha¬lmo¬logical gel comprises 0.2-0.5% low-cross-linked polyacrylic acid and/or derivatives thereof, preservatives, stabilisers, a medicinal substance selected from a reparant group and clean water, and has a pH value within the range of lachrymal liquid. The gel contains 1-(ß-oxyethyl)-4,6-dimethyl-1,2-dihydro-2-oxypyrimidine (xymedon) in the form of a medicinal substance from a reparant group. The method for gel production consists in adding an aqueous 10-30% polyethylenoxide solution into a dry powder of low-cross-linked polyacrylic acid associated with rapid agitation, polyethylenoxide being taken at least in a tenfold excess with respect to the mass of the powder, in adding, while agitating, clean water in a quantity equal to 70-90% the total mass of the gel, in adjusting a pH value to a value of 6.0-7.0 by means of a sodium hydroxide solution, in adding, while agitating, an alkali stabiliser, preservative and antibiotic solution, which is previously prepared in a separate reactor, by mixing the aqueous solutions of benzalkonium chloride, bisodium edetate and gentamicin sulphate, in subsequently adding a 10-20% sodium hydroxide solution, in adding xymedon at a mass concentration of 1-10%, in adjusting, for the second time, the pH value to a required value by means of a sodium hydroxide solution and in sterilising the thus produced gel.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2007116779/15A RU2340327C1 (en) | 2007-05-03 | 2007-05-03 | Ophthalmologic gel and method of its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GEP20115350B true GEP20115350B (en) | 2011-12-12 |
Family
ID=39943722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP200811585A GEP20115350B (en) | 2007-05-03 | 2008-04-23 | Ophthalmological gel and a method for the use thereof |
Country Status (5)
| Country | Link |
|---|---|
| EA (1) | EA018202B1 (en) |
| GE (1) | GEP20115350B (en) |
| RU (1) | RU2340327C1 (en) |
| UA (1) | UA96193C2 (en) |
| WO (1) | WO2008136707A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2402316C2 (en) * | 2009-01-11 | 2010-10-27 | Пшеничников Виталий Георгиевич | Pharmaceutical antiglaucoma composition |
| RU2428988C1 (en) * | 2010-07-26 | 2011-09-20 | Государственное образовательное учреждение высшего профессионального образования "Кемеровский государственный университет" (КемГУ) | Method of obtaining ion-exchanging polymer hyrdogels for treatment of chemical burns of eyes (versions) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5252318A (en) * | 1990-06-15 | 1993-10-12 | Allergan, Inc. | Reversible gelation compositions and methods of use |
| SE9401108D0 (en) * | 1994-03-31 | 1994-03-31 | Leiras Oy | Ophthalmic composition I |
| DE60033307T2 (en) * | 1999-10-21 | 2007-07-12 | F. Hoffmann-La Roche Ag | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS P38 PROTEIN KINASE INHIBITORS |
| RU2211037C1 (en) * | 2001-12-29 | 2003-08-27 | Институт органической и физической химии им. А.Е.Арбузова Казанского научного центра РАН | Preparation with selective effect and method for treatment of osteoarthrosis |
-
2007
- 2007-05-03 RU RU2007116779/15A patent/RU2340327C1/en active
-
2008
- 2008-04-23 WO PCT/RU2008/000259 patent/WO2008136707A1/en not_active Ceased
- 2008-04-23 EA EA200901480A patent/EA018202B1/en not_active IP Right Cessation
- 2008-04-23 UA UAA200912475A patent/UA96193C2/en unknown
- 2008-04-23 GE GEAP200811585A patent/GEP20115350B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA018202B1 (en) | 2013-06-28 |
| WO2008136707A1 (en) | 2008-11-13 |
| EA200901480A1 (en) | 2010-04-30 |
| UA96193C2 (en) | 2011-10-10 |
| RU2340327C1 (en) | 2008-12-10 |
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