GEP20084424B - Sedative and spasmolytic medicinal agent and method for the production thereof (variants) - Google Patents

Sedative and spasmolytic medicinal agent and method for the production thereof (variants)

Info

Publication number
GEP20084424B
GEP20084424B GEAP200510059A GEAP2005010059A GEP20084424B GE P20084424 B GEP20084424 B GE P20084424B GE AP200510059 A GEAP200510059 A GE AP200510059A GE AP2005010059 A GEAP2005010059 A GE AP2005010059A GE P20084424 B GEP20084424 B GE P20084424B
Authority
GE
Georgia
Prior art keywords
cyclodextrine
phenobarbital
pill
mixture
medicinal agent
Prior art date
Application number
GEAP200510059A
Inventor
Viktor Rybchuk
Original Assignee
Viktor Rybchuk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from UA20041008756A external-priority patent/UA81623C2/en
Application filed by Viktor Rybchuk filed Critical Viktor Rybchuk
Publication of GEP20084424B publication Critical patent/GEP20084424B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to medicine. The inventive sedative and spasmolytic medicinal agent comprises an ά bromomethyl butanoic acid ethyl ether, phenobarbital, brandy mint oil, microcrystalline cellulose and adjuvants for forming solid dosage form (pills) which are coated with a shell containing ß cyclodextrine or the derivatives thereof. The first variant of a method for producing said medicinal agent consists in mixing the ά bromomethyl butanoic acid ethyl ether with the brandy mint oil, adding said mixture into the humidified ß cyclodextrine, stirring for 1-2 minutes, drying, granulating, in mixing the granulate with the phenobarbital, microcrystalline cellulose and adjuvant powders, pressing a pill and coating said pill with the ß cyclodextrine-containing shell. The second variant of said method consists in mixing the phenobarbital with the adjuvant-filler, separately preparing the mixture of the ά bromo-methyl butanoic acid ethyl ether and the brandy mint oil, adding the microcrystalline cellulose, developed crystal face powders, openers and sliding agents, in adding said mixture into the phenobarbital-filler mixture, pressing a pill and in coating said pill with the ß cyclodextrine-containing shell.
GEAP200510059A 2004-10-26 2005-10-26 Sedative and spasmolytic medicinal agent and method for the production thereof (variants) GEP20084424B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
UA20041008756A UA81623C2 (en) 2004-10-26 2004-10-26 A process for the preparation of the drug of sedative and spasmolytic action
UA20041008755 2004-10-26

Publications (1)

Publication Number Publication Date
GEP20084424B true GEP20084424B (en) 2008-07-10

Family

ID=36228091

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP200510059A GEP20084424B (en) 2004-10-26 2005-10-26 Sedative and spasmolytic medicinal agent and method for the production thereof (variants)

Country Status (3)

Country Link
GE (1) GEP20084424B (en)
RU (1) RU2349334C2 (en)
WO (1) WO2006046933A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2563190C2 (en) * 2012-06-14 2015-09-20 Открытое Акционерное Общество "Татхимфармпрераты" Medication based on dry extracts of medicinal plants and method of obtaining thereof (versions)
EA021571B1 (en) * 2013-04-17 2015-07-30 Общество с ограниченной ответственностью "ЮжФарм" Method for preparing tableted mass from active pharmaceutical substances having sedative and spasmolytic action
RU2589833C2 (en) * 2013-12-12 2016-07-10 Общество С Ограниченной Ответственностью "Фарма Старт" Solid dosage form of preparation of sedative and hypnotic effect
RU2578432C9 (en) * 2015-03-02 2016-06-20 Общество с ограниченной ответственностью "Трейдсервис" Method of obtaining a solid form of the drug sedative and antispasmodic action
RU2633064C2 (en) * 2015-09-18 2017-10-11 Закрытое акционерное общество "Московская фармацевтическая фабрика" Sedative and spasmolithic means and method for its production
CN107582530A (en) * 2017-06-01 2018-01-16 合肥远志医药科技开发有限公司 A kind of Kotabarb and preparation method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0166088B1 (en) * 1990-01-23 1999-01-15 . Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof

Also Published As

Publication number Publication date
RU2007118240A (en) 2008-12-10
WO2006046933A1 (en) 2006-05-04
RU2349334C2 (en) 2009-03-20

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