WO2006101462A3 - Pharmaceutical preparation comprising perindopril erbumine and method of preparation and stabilisation thereof - Google Patents

Pharmaceutical preparation comprising perindopril erbumine and method of preparation and stabilisation thereof Download PDF

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Publication number
WO2006101462A3
WO2006101462A3 PCT/SK2006/000008 SK2006000008W WO2006101462A3 WO 2006101462 A3 WO2006101462 A3 WO 2006101462A3 SK 2006000008 W SK2006000008 W SK 2006000008W WO 2006101462 A3 WO2006101462 A3 WO 2006101462A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
tablets
excipient
compound
pharmaceutical preparation
Prior art date
Application number
PCT/SK2006/000008
Other languages
French (fr)
Other versions
WO2006101462A2 (en
Inventor
Lubos Mgr Dorsic
Vendelin Smahovsky
Viera Barigova
Jana Psenkova
Ladislav Jezek
Valdemar Stalmach
Ivan Varga
Original Assignee
Vulm A S
Lubos Mgr Dorsic
Vendelin Smahovsky
Viera Barigova
Jana Psenkova
Ladislav Jezek
Valdemar Stalmach
Ivan Varga
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vulm A S, Lubos Mgr Dorsic, Vendelin Smahovsky, Viera Barigova, Jana Psenkova, Ladislav Jezek, Valdemar Stalmach, Ivan Varga filed Critical Vulm A S
Publication of WO2006101462A2 publication Critical patent/WO2006101462A2/en
Publication of WO2006101462A3 publication Critical patent/WO2006101462A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The subject matter of the invention is a pharmaceutical preparation comprising perindopril erbumine in a stable form within the rage 1 to 40 % by weight and at least one excipient and/or a mixture of excipients within the range 1 % - 99 % by weight, whereas at least one excipient is a substance of basic character maintaining pH 7.1 to 14. The subject matters of the invention are also a method of preparing, stabilising and packing of an oral pharmaceutical preparation in the dosage form of tablets, and/or coated tablets, and/or capsules which is used as an oral therapeutic of hypertension. The principle of manufacturing method consists in preparation of a compound comprising an alkalising excipient by dry mixing of powder components, and/or briqueting, and/or compacting, and modification of particle size of a compound. The compound prepared in this way may be used for compression of tablet cores, and/or tablets, and/or micro-tablets, and/or preparation of pellets, and/or micro-pellets, and/or powders and/or granules, and/or fill in capsules.
PCT/SK2006/000008 2005-03-22 2006-03-17 Pharmaceutical preparation comprising perindopril erbumine and method of preparation and stabilisation thereof WO2006101462A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SKPP5025-2005 2005-03-22
SK5025-2005A SK50252005A3 (en) 2005-03-22 2005-03-22 Pharmaceutical composition containing perindopril erbumine, method of its preparation and stabilisation

Publications (2)

Publication Number Publication Date
WO2006101462A2 WO2006101462A2 (en) 2006-09-28
WO2006101462A3 true WO2006101462A3 (en) 2006-12-28

Family

ID=37024245

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SK2006/000008 WO2006101462A2 (en) 2005-03-22 2006-03-17 Pharmaceutical preparation comprising perindopril erbumine and method of preparation and stabilisation thereof

Country Status (2)

Country Link
SK (1) SK50252005A3 (en)
WO (1) WO2006101462A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0615607A2 (en) * 2005-08-30 2011-05-24 Lek Pharmaceuticals pharmaceutical composition comprising perindopril or its salts
RU2008145115A (en) * 2006-04-19 2010-05-27 Тева Фармасьютикл Индастриес Лтд. (Il) STABLE PHARMACEUTICAL COMPOSITIONS OF PRODUCTION COMPOUNDS OF 2-AZA-Bicyclo [3.3.0] -OKTAN-3-CARBONIC ACID
SI22543A (en) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto New salts of perindopril
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003061691A1 (en) * 2002-01-23 2003-07-31 Les Laboratoires Servier Orodispersible pharmaceutical composition comprising perindopril
US20040115227A1 (en) * 2000-12-26 2004-06-17 Patrick Wuthrich Thermoformable solid pharmaceutical composition for controlled release of perindopril
JP2004346066A (en) * 2003-04-30 2004-12-09 Dai Ichi Seiyaku Co Ltd Stabilized solid formulation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040115227A1 (en) * 2000-12-26 2004-06-17 Patrick Wuthrich Thermoformable solid pharmaceutical composition for controlled release of perindopril
WO2003061691A1 (en) * 2002-01-23 2003-07-31 Les Laboratoires Servier Orodispersible pharmaceutical composition comprising perindopril
JP2004346066A (en) * 2003-04-30 2004-12-09 Dai Ichi Seiyaku Co Ltd Stabilized solid formulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 2003, no. 12 5 December 2003 (2003-12-05) *

Also Published As

Publication number Publication date
WO2006101462A2 (en) 2006-09-28
SK50252005A3 (en) 2006-10-05

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