GB999892A - Dialkylaminoalkyl esters of substituted phenoxyphenyl alkanoic acids - Google Patents

Dialkylaminoalkyl esters of substituted phenoxyphenyl alkanoic acids

Info

Publication number
GB999892A
GB999892A GB33921/62A GB3392162A GB999892A GB 999892 A GB999892 A GB 999892A GB 33921/62 A GB33921/62 A GB 33921/62A GB 3392162 A GB3392162 A GB 3392162A GB 999892 A GB999892 A GB 999892A
Authority
GB
United Kingdom
Prior art keywords
compounds
formula
diiodo
refluxing
isopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33921/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of GB999892A publication Critical patent/GB999892A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/10—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of a carbon skeleton containing rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of general formula <FORM:0999892/C2/1> wherein each of R and R1 is hydrogen, iodo or alkyl, B is hydrogen or alkyl, n is 0 to 3, and x is 2 or 3; and their pharmaceutically acceptable non-toxic acid addition salts; and their preparation by reacting a compound of formula <FORM:0999892/C2/2> with a compound of formula <FORM:0999892/C2/3> in an inert organic solvent. 4- (3 - Isopropyl - 4 - hydroxy - phenoxy) - 3,5 - diiodo - phenyl - acetic acid is prepared by reaction of ethyl 3,5-diiodo-4-hydroxy-phenyl acetate and di-(2-isopropyl-methoxyphenyl)-iodonium sulphate (obtained from the bromide using silver sulphate) by refluxing in methanol with sodium methoxide, followed by refluxing the product with acetic and hydriodic acids. Pharmaceutical compositions comprise the compounds I and their non-toxic acid addition salts together with pharmaceutical carriers. Oral administration of tablets, capsules, solutions and sustained release compositions is mentioned. The compounds lower cholesterol levels in the blood. Reference has been directed by the Comptroller to Specification 911,344.
GB33921/62A 1961-09-28 1962-09-04 Dialkylaminoalkyl esters of substituted phenoxyphenyl alkanoic acids Expired GB999892A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US141313A US3064037A (en) 1961-09-28 1961-09-28 Dialkylaminoalkyl phenoxyphenylalkanoates

Publications (1)

Publication Number Publication Date
GB999892A true GB999892A (en) 1965-07-28

Family

ID=22495153

Family Applications (1)

Application Number Title Priority Date Filing Date
GB33921/62A Expired GB999892A (en) 1961-09-28 1962-09-04 Dialkylaminoalkyl esters of substituted phenoxyphenyl alkanoic acids

Country Status (2)

Country Link
US (1) US3064037A (en)
GB (1) GB999892A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3462473A (en) * 1967-03-06 1969-08-19 Upjohn Co Phenoxyphenyl alkanesulfonates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2844621A (en) * 1955-11-01 1958-07-22 Olin Mathieson Alkylaminoalkyl 4-alkoxy-2, 6-dialkylbenzoates
US2970165A (en) * 1957-10-01 1961-01-31 Warner Lambert Pharmaceutical Sulfate compounds
US2928845A (en) * 1958-04-09 1960-03-15 Us Vitamin Pharm Corp Dialkylaminoalkoxyphenylethanol esters

Also Published As

Publication number Publication date
US3064037A (en) 1962-11-13

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