GB999091A - Benzo(a)quinolizine derivatives and method for making them - Google Patents
Benzo(a)quinolizine derivatives and method for making themInfo
- Publication number
- GB999091A GB999091A GB3993459A GB3993459A GB999091A GB 999091 A GB999091 A GB 999091A GB 3993459 A GB3993459 A GB 3993459A GB 3993459 A GB3993459 A GB 3993459A GB 999091 A GB999091 A GB 999091A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- benzo
- making
- compounds
- lower alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- RMOYSWDTCQZJGS-UHFFFAOYSA-N 6h-benzo[a]quinolizine Chemical class C1=CC=CN2CC=C(C=CC=C3)C3=C21 RMOYSWDTCQZJGS-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- SSSYOIPHXANRMO-UHFFFAOYSA-N 4h-benzo[a]quinolizine Chemical class C1=CC=C2C3=CC=CCN3C=CC2=C1 SSSYOIPHXANRMO-UHFFFAOYSA-N 0.000 abstract 1
- MBYXEBXZARTUSS-QLWBXOBMSA-N Emetamine Natural products O(C)c1c(OC)cc2c(c(C[C@@H]3[C@H](CC)CN4[C@H](c5c(cc(OC)c(OC)c5)CC4)C3)ncc2)c1 MBYXEBXZARTUSS-QLWBXOBMSA-N 0.000 abstract 1
- AUVVAXYIELKVAI-UHFFFAOYSA-N SJ000285215 Natural products N1CCC2=CC(OC)=C(OC)C=C2C1CC1CC2C3=CC(OC)=C(OC)C=C3CCN2CC1CC AUVVAXYIELKVAI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- AUVVAXYIELKVAI-CKBKHPSWSA-N emetine Chemical compound N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@@H]1CC AUVVAXYIELKVAI-CKBKHPSWSA-N 0.000 abstract 1
- 229960002694 emetine Drugs 0.000 abstract 1
- AUVVAXYIELKVAI-UWBTVBNJSA-N emetine Natural products N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@H]1CC AUVVAXYIELKVAI-UWBTVBNJSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3993459A GB999091A (en) | 1959-11-24 | 1959-11-24 | Benzo(a)quinolizine derivatives and method for making them |
| CH1308460A CH409969A (de) | 1959-11-24 | 1960-11-22 | Verfahren zur Herstellung von Benzo(a)chinolizinen |
| MC275A MC247A1 (fr) | 1959-11-24 | 1960-11-22 | Dérivés de la benzo (a) quinolizine et leur préparation |
| CS703860A CS161683B2 (enrdf_load_stackoverflow) | 1959-11-24 | 1960-11-23 | |
| ES0262676A ES262676A1 (es) | 1959-11-24 | 1960-11-23 | Un metodo de hacer emetina o sus analogos |
| FI193960A FI41401B (enrdf_load_stackoverflow) | 1959-11-24 | 1960-11-23 | |
| LU39451D LU39451A1 (enrdf_load_stackoverflow) | 1959-11-24 | 1960-11-24 | |
| CH611061A CH442314A (de) | 1959-11-24 | 1961-05-25 | Verfahren zur Racemisierung der optisch aktiven Enantiomeren von 3-Äthyl-1,2,3,4,6,7-hexahydro-9,10-dimethoxy-2-oxo-11bH-benzo(a)chinolizin |
| BR12951161A BR6129511D0 (pt) | 1959-11-24 | 1961-05-26 | Um processo para a racemizacao de uma etil-1,2,3,4,6,7-hexa-hidro -9,10-dimetoxi-2-oxa 11 bh-benzo(a)-quiquinolizina oticamente ativa e separar seus enanciomeros oticos |
| DE19611303629D DE1303629C2 (de) | 1959-11-24 | 1961-05-26 | Verfahren zur gewinnung des (+)oder (-)-enantiomeren des 3-aethyl-1,2,3, 4,6,7-hexahydro-9,10-dimethoxy-2-oxollb-benzo(a)chinolizins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3993459A GB999091A (en) | 1959-11-24 | 1959-11-24 | Benzo(a)quinolizine derivatives and method for making them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB999091A true GB999091A (en) | 1965-07-21 |
Family
ID=10412290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3993459A Expired GB999091A (en) | 1959-11-24 | 1959-11-24 | Benzo(a)quinolizine derivatives and method for making them |
Country Status (7)
| Country | Link |
|---|---|
| CH (1) | CH409969A (enrdf_load_stackoverflow) |
| CS (1) | CS161683B2 (enrdf_load_stackoverflow) |
| ES (1) | ES262676A1 (enrdf_load_stackoverflow) |
| FI (1) | FI41401B (enrdf_load_stackoverflow) |
| GB (1) | GB999091A (enrdf_load_stackoverflow) |
| LU (1) | LU39451A1 (enrdf_load_stackoverflow) |
| MC (1) | MC247A1 (enrdf_load_stackoverflow) |
-
1959
- 1959-11-24 GB GB3993459A patent/GB999091A/en not_active Expired
-
1960
- 1960-11-22 MC MC275A patent/MC247A1/xx unknown
- 1960-11-22 CH CH1308460A patent/CH409969A/de unknown
- 1960-11-23 ES ES0262676A patent/ES262676A1/es not_active Expired
- 1960-11-23 CS CS703860A patent/CS161683B2/cs unknown
- 1960-11-23 FI FI193960A patent/FI41401B/fi active
- 1960-11-24 LU LU39451D patent/LU39451A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH409969A (de) | 1966-03-31 |
| MC247A1 (fr) | 1961-06-15 |
| LU39451A1 (enrdf_load_stackoverflow) | 1961-05-24 |
| FI41401B (enrdf_load_stackoverflow) | 1969-07-31 |
| ES262676A1 (es) | 1961-04-16 |
| CS161683B2 (enrdf_load_stackoverflow) | 1975-06-10 |
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