GB994547A - Steroids - Google Patents
SteroidsInfo
- Publication number
- GB994547A GB994547A GB142764A GB142764A GB994547A GB 994547 A GB994547 A GB 994547A GB 142764 A GB142764 A GB 142764A GB 142764 A GB142764 A GB 142764A GB 994547 A GB994547 A GB 994547A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formyl
- pregnadien
- carbon atoms
- pregnatriene
- diacetal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Abstract
The invention comprises a pregnenolone or progesterone derivative having the formula <FORM:0994547/C2/1> wherein R = an alkyl or aralkyl group having 1-9 carbon atoms; R1 = H(b -OH), H (b -OAc) or O, and when R1 = H(b -OH) or H(b -OAc) there is a double bond in the 5,6-position, while when R1 = O there is a double bond in the 4,5-position; Ac = a radical of a carboxylic acid having 1-9 carbon atoms; <FORM:0994547/C2/2> and a process for the preparation thereof which includes the reaction of a 5,16-pregnadien-3b -ol - 20 - one - 3 - acyl ester - 20 - ketal with phosphorus oxychloride or phosgene and dimethylformamide to give the corresponding 21-formyl - 20 - (21 - chloroethoxy) - 5,16,20-pregnatriene - 3b - ol - 3 - acylester, the alkaline hydrolysis of the product to yield 21-formyl-20 - (21 - chloroethoxy) - 5,16,20 - pregnatriene-3b -ol and reaction of this product with an alcohol having from 1-9 carbon atoms in the molecule in the presence of a dilute inorganic acid to give a 21-formyl-5,16-pregnadien-3b -ol-20-one diacetal, and where necessary, oxidation or esterification. Oxidation of 21-formyl-5,16-pregnadien-3b -ol-20-one diacetal with alkaline hydrogen peroxide gives the corresponding 11a ,17a -epoxide. Pharmaceutical compositions containing the above compounds and having antiinflammatory, antirheumatic, and antiallergic activity are administered orally, parenterally or topically as tablets, pills, powders, ointments, solutions, suspensions and emulsions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98063 | 1963-01-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB994547A true GB994547A (en) | 1965-06-10 |
Family
ID=11100252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB142764A Expired GB994547A (en) | 1963-01-17 | 1964-01-13 | Steroids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB994547A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001022959A2 (en) * | 1999-09-28 | 2001-04-05 | University Of Pennsylvania | Compositions comprising progesterone or progesterone analogs for the treatment of inflammatory conditions |
-
1964
- 1964-01-13 GB GB142764A patent/GB994547A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001022959A2 (en) * | 1999-09-28 | 2001-04-05 | University Of Pennsylvania | Compositions comprising progesterone or progesterone analogs for the treatment of inflammatory conditions |
| WO2001022959A3 (en) * | 1999-09-28 | 2001-10-04 | Univ Pennsylvania | Compositions comprising progesterone or progesterone analogs for the treatment of inflammatory conditions |
| JP2003510277A (en) * | 1999-09-28 | 2003-03-18 | ユニバーシティー オブ ペンシルバニア | Treatment of inflammation with progesterone or progesterone analog |
| US6610674B1 (en) | 1999-09-28 | 2003-08-26 | University Of Pennsylvania | Method of treating inflammatory conditions with progesterone analogs |
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