GB991933A - Tetracyclic aromatic diene compounds - Google Patents

Tetracyclic aromatic diene compounds

Info

Publication number
GB991933A
GB991933A GB6864/61A GB686461A GB991933A GB 991933 A GB991933 A GB 991933A GB 6864/61 A GB6864/61 A GB 6864/61A GB 686461 A GB686461 A GB 686461A GB 991933 A GB991933 A GB 991933A
Authority
GB
United Kingdom
Prior art keywords
group
hydroxy
acyloxy
substituted
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6864/61A
Inventor
Herchel Smith
Gordon Alan Hughes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB6864/61A priority Critical patent/GB991933A/en
Priority to DE19621468561 priority patent/DE1468561B1/en
Priority to CH112166A priority patent/CH410935A/en
Priority to DE19621793607 priority patent/DE1793607A1/en
Priority to CH211262A priority patent/CH419110A/en
Priority to SE1989/62A priority patent/SE312803B/xx
Priority to DK86962AA priority patent/DK109387C/en
Priority to ES0274888A priority patent/ES274888A1/en
Priority to DK67863AA priority patent/DK113921B/en
Publication of GB991933A publication Critical patent/GB991933A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26B—HAND-HELD CUTTING TOOLS NOT OTHERWISE PROVIDED FOR
    • B26B19/00—Clippers or shavers operating with a plurality of cutting edges, e.g. hair clippers, dry shavers
    • B26B19/28—Drive layout for hair clippers or dry shavers, e.g. providing for electromotive drive
    • B26B19/32—Drive layout for hair clippers or dry shavers, e.g. providing for electromotive drive providing for mechanical drive, e.g. installation of a spring motor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Forests & Forestry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The invention comprises (1) a process for preparing compounds of the formula <FORM:0991933/C2/1> (wherein each R is hydrogen or alkyl, R1 is a saturated or unsaturated aliphatic hydrocarbon radical, Q is methylene or ethylene, Y is hydroxymethylene, acyloxymethylene or a ketalized carbonyl group and the o-phenylene group is substituted by one or more hydroxy, acyloxy or alkoxy groups, at least one such group being present in the 3-position) by reducing, reducing and esterifying or ketalizing a compound of the above structure wherein Y is a carbonyl group; and (2) compounds of the above structure wherein R, R1, Q and Y are as defined above and the o-phenylene group is substituted in the 3-position by a hydroxy, acyloxy or alkoxy group. The reduction is preferably performed with a borohydride or with lithium aluminium hydride. Acylation may be effected with an organic acid, particularly a carboxylic acid, and ketalization with, for example, methanol or ethanol or a glycol. In the products, a 3-hydroxy group can be acylated. Also, the products may be converted to 8-iso-steroids by hydrogenation, using a platinum catalyst to saturate both ethylenic linkages. Diene ketone starting materials may be prepared in situ by the process described in Specification 991,592. Examples are given.
GB6864/61A 1961-02-24 1961-02-24 Tetracyclic aromatic diene compounds Expired GB991933A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
GB6864/61A GB991933A (en) 1961-02-24 1961-02-24 Tetracyclic aromatic diene compounds
DE19621468561 DE1468561B1 (en) 1961-02-24 1962-02-21 Process for the preparation of 13-alkylgona-1,3,5 (10), 8,14-pentaenes
CH112166A CH410935A (en) 1961-02-24 1962-02-21 Manufacturing process for polycyclic aromatic diene compounds
DE19621793607 DE1793607A1 (en) 1961-02-24 1962-02-21 13-alkylgona-1,3,5 (10), 8,14-pentaenes
CH211262A CH419110A (en) 1961-02-24 1962-02-21 Manufacturing process for polycyclic aromatic dienes
SE1989/62A SE312803B (en) 1961-02-24 1962-02-23
DK86962AA DK109387C (en) 1961-02-24 1962-02-23 Process for the preparation of ketals of Δ <1,3,5 (10), 8,14> -17-oxosteroid or -D-homosteroid compounds.
ES0274888A ES274888A1 (en) 1961-02-24 1962-02-23 Procedure for preparing polycyclic aromatic dienical compounds (Machine-translation by Google Translate, not legally binding)
DK67863AA DK113921B (en) 1961-02-24 1963-02-13 Process for the preparation of Δ <1,3,5, (10), 8,14> -17-hydroxy-steroid or -D-homosteroid compounds or 17-esters thereof.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB6864/61A GB991933A (en) 1961-02-24 1961-02-24 Tetracyclic aromatic diene compounds

Publications (1)

Publication Number Publication Date
GB991933A true GB991933A (en) 1965-05-12

Family

ID=9822158

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6864/61A Expired GB991933A (en) 1961-02-24 1961-02-24 Tetracyclic aromatic diene compounds

Country Status (6)

Country Link
CH (2) CH419110A (en)
DE (2) DE1793607A1 (en)
DK (2) DK109387C (en)
ES (1) ES274888A1 (en)
GB (1) GB991933A (en)
SE (1) SE312803B (en)

Also Published As

Publication number Publication date
CH419110A (en) 1966-08-31
DE1793607A1 (en) 1972-04-13
DK109387C (en) 1968-04-22
SE312803B (en) 1969-07-28
DE1468561B1 (en) 1970-08-20
DK113921B (en) 1969-05-12
ES274888A1 (en) 1962-04-01
CH410935A (en) 1966-04-15

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