GB920270A - Improvements in or relating to the production of steroid derivatives - Google Patents

Improvements in or relating to the production of steroid derivatives

Info

Publication number
GB920270A
GB920270A GB3470259A GB3470259A GB920270A GB 920270 A GB920270 A GB 920270A GB 3470259 A GB3470259 A GB 3470259A GB 3470259 A GB3470259 A GB 3470259A GB 920270 A GB920270 A GB 920270A
Authority
GB
United Kingdom
Prior art keywords
keto
group
acyloxylation
acyloxy
relating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3470259A
Inventor
Harold Bernard Henbest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to GB3470259A priority Critical patent/GB920270A/en
Priority to BE595951A priority patent/BE595951A/en
Priority to BR12344160A priority patent/BR6023441D0/en
Priority to CH1149460A priority patent/CH385198A/en
Publication of GB920270A publication Critical patent/GB920270A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

21-Acyloxy-20-keto steroids are prepared by 21-acyloxylation of the 21-unsubstituted keto steroid using a lead tetraacylate in the presence of boron trifluoride and in a solvent medium comprising a mixture of a hydrocarbon solvent and an alcohol. Preferably the reaction is effected at room temperature with lead tetraacetate and boron trifluoride etherate in a benzene-methanol mixture. The process is suitable for the acyloxylation of pregnane-20-ones of the 5a - and 5b -series containing, if desired, a keto, acyloxy or hydroxy group at C3, a keto group at C11, a keto group at C12 and/or a methyl group at C16, and which may be unsaturated at one or more of the following positions 1(2), 4(5), 5(6), 9(11) and 16(17). The invention is illustrated by 8 detailed examples.
GB3470259A 1959-10-13 1959-10-13 Improvements in or relating to the production of steroid derivatives Expired GB920270A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB3470259A GB920270A (en) 1959-10-13 1959-10-13 Improvements in or relating to the production of steroid derivatives
BE595951A BE595951A (en) 1959-10-13 1960-10-12 Improvements in the production of steroid compounds.
BR12344160A BR6023441D0 (en) 1959-10-13 1960-10-13 PERFECT PROCESS FOR A-21-ACETROXYLATION OF 20 KETO-STEROIDS
CH1149460A CH385198A (en) 1959-10-13 1960-10-13 Process for making keto steroids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3470259A GB920270A (en) 1959-10-13 1959-10-13 Improvements in or relating to the production of steroid derivatives

Publications (1)

Publication Number Publication Date
GB920270A true GB920270A (en) 1963-03-06

Family

ID=10368898

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3470259A Expired GB920270A (en) 1959-10-13 1959-10-13 Improvements in or relating to the production of steroid derivatives

Country Status (4)

Country Link
BE (1) BE595951A (en)
BR (1) BR6023441D0 (en)
CH (1) CH385198A (en)
GB (1) GB920270A (en)

Also Published As

Publication number Publication date
CH385198A (en) 1964-12-15
BE595951A (en) 1961-04-12
BR6023441D0 (en) 1973-05-24

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