GB990340A - Basic ether derivatives of n,ª‰-disubstituted-ª‡-phenethylamines - Google Patents

Basic ether derivatives of n,ª‰-disubstituted-ª‡-phenethylamines

Info

Publication number
GB990340A
GB990340A GB42159/63A GB4215963A GB990340A GB 990340 A GB990340 A GB 990340A GB 42159/63 A GB42159/63 A GB 42159/63A GB 4215963 A GB4215963 A GB 4215963A GB 990340 A GB990340 A GB 990340A
Authority
GB
United Kingdom
Prior art keywords
compounds
group
reacting
anil
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB42159/63A
Inventor
Edward Delbert Amstutz
Franz Patrick Palopoli
Charles Harmon Tilford
Richard Ferriss Shuman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Priority to GB42159/63A priority Critical patent/GB990340A/en
Priority to FR953448A priority patent/FR3313M/en
Publication of GB990340A publication Critical patent/GB990340A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0990340/C2/1> in which one of X and Y is a pyridyl, piperidyl or N-lower alkyl piperidyl group, and the other is a phenyl, halophenyl, trifluoromethylphenyl, lower alkylphenyl, or lower alkoxyphenyl group, n is 2, 3, or 4, and Am is a di-lower alkylamino, morpholino, piperidino or pyrrolidino group, the nitrogen atom of the group being attached to the -(CH2)ngroup, and non-toxic acid addition and quaternary salts thereof. The compounds are prepared by reacting an anil of formula <FORM:0990340/C2/2> with an organo metallic, preferably lithium derivative of Y, hydrogenating the compound obtained and decomposing with water to obtain the product. The N-lower alkyl piperidine compounds are prepared by reacting the piperidine compound with an acid chloride followed by reduction with lithium aluminium hydride. The anil starting material is produced by reacting a basic ether substituted benzaldehyde with an amine derivative of X or Y. The compounds are used in therapeutic compositions together with a therapeutically acceptable carrier.
GB42159/63A 1963-10-25 1963-10-25 Basic ether derivatives of n,ª‰-disubstituted-ª‡-phenethylamines Expired GB990340A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB42159/63A GB990340A (en) 1963-10-25 1963-10-25 Basic ether derivatives of n,ª‰-disubstituted-ª‡-phenethylamines
FR953448A FR3313M (en) 1963-10-25 1963-11-12 Basic ethers derivatives of n, β-disubstituted α-phenethylamines.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB42159/63A GB990340A (en) 1963-10-25 1963-10-25 Basic ether derivatives of n,ª‰-disubstituted-ª‡-phenethylamines

Publications (1)

Publication Number Publication Date
GB990340A true GB990340A (en) 1965-04-28

Family

ID=10423122

Family Applications (1)

Application Number Title Priority Date Filing Date
GB42159/63A Expired GB990340A (en) 1963-10-25 1963-10-25 Basic ether derivatives of n,ª‰-disubstituted-ª‡-phenethylamines

Country Status (2)

Country Link
FR (1) FR3313M (en)
GB (1) GB990340A (en)

Also Published As

Publication number Publication date
FR3313M (en) 1965-05-17

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