GB981533A - Derivatives of phenylalanine - Google Patents

Derivatives of phenylalanine

Info

Publication number
GB981533A
GB981533A GB675762A GB675762A GB981533A GB 981533 A GB981533 A GB 981533A GB 675762 A GB675762 A GB 675762A GB 675762 A GB675762 A GB 675762A GB 981533 A GB981533 A GB 981533A
Authority
GB
United Kingdom
Prior art keywords
compound
formula
group
reacting
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB675762A
Inventor
Frederick William Bollinger
Meyer Sletzinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to GB675762A priority Critical patent/GB981533A/en
Publication of GB981533A publication Critical patent/GB981533A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises racemic compounds of the general formula <FORM:0981533/C2/1> (wherein R1 is a hydrogen atom or a methyl group, R* is a C1- 5 alkyl group, R0 is a hydrogen atom or a C1- 5 alkyl group and X is an OR1 group in the 4- or 5-position, being identical to the OR1 group in the 2-position) and non-toxic acid addition salts thereof, pharmaceutical preparations containing them, and their preparation by reacting a compound of the formula <FORM:0981533/C2/2> (wherein X0 is a methoxy group in the 4- or 5-position) with ammonium carbonate and a water-soluble cyanide salt to form a compound of the formula <FORM:0981533/C2/3> reacting the latter compound with a base to form a salt of a racemic compound of the formula <FORM:0981533/C2/4> and acidifying to produce the free acid form of that compound, optionally followed by one or more of the steps (a) demethylation with an aqueous hydrohalic acid, (b) esterification with a C1- 5 alkanol, and (c) acid addition salt formation. The starting materials are prepared by reacting a compound of the formula <FORM:0981533/C2/5> with R*CH2NO2 and reducing the product with iron and hydrochloric acid. The compounds of the invention are useful in the treatment of hypertension, and may be administered orally or parenterally in the form of pharmaceutical preparations (e.g. capsules, tablets, solutions and suspensions) containing them together with a diluent or carrier. Specification 936,074 is referred to.
GB675762A 1962-02-21 1962-02-21 Derivatives of phenylalanine Expired GB981533A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB675762A GB981533A (en) 1962-02-21 1962-02-21 Derivatives of phenylalanine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB675762A GB981533A (en) 1962-02-21 1962-02-21 Derivatives of phenylalanine

Publications (1)

Publication Number Publication Date
GB981533A true GB981533A (en) 1965-01-27

Family

ID=9820224

Family Applications (1)

Application Number Title Priority Date Filing Date
GB675762A Expired GB981533A (en) 1962-02-21 1962-02-21 Derivatives of phenylalanine

Country Status (1)

Country Link
GB (1) GB981533A (en)

Similar Documents

Publication Publication Date Title
GB1063749A (en) New guanidine derivatives and processes for their production
GB1262965A (en) Butyrophenones
GB1456627A (en) Pyridobenzodiazepinones
GB1016071A (en) New guanidine derivatives and process for preparing the same
GB1137764A (en) Improvements in or relating to pharmacologically-active secondary amines
GB1363195A (en) Propenylamine derivatives and process for the production thereof
ES454063A1 (en) Novel benzylalcohol derivatives and processes for preparing the same
GB1394568A (en) Diazepine derivatives and process for the production thereof
GB1462036A (en) Aminoindane derivatives
GB1219609A (en) Diphenylmethoxyethylamino derivatives
GB981533A (en) Derivatives of phenylalanine
GB1016240A (en) Guanidine derivatives and a process for the manufacture thereof
GB935525A (en) Anthranilic acids and method for producing the same
GB1026401A (en) Isatin thiosemicarbazones,their preparation and pharmaceutical formulations containing them
GB1529972A (en) Basic alcohols
GB1290841A (en)
GB1466462A (en) Amines and process for their manufacture
SE9001236D0 (en) PREPARATION OF SUBSTITUTED ETHENS
GB1148288A (en) A process for the manufacture of benzdiaz[1,4]epine derivatives
GB1254270A (en) Benzoxazepine derivatives
ES286809A1 (en) Novel benzoxazepine derivatives and a process for the manufacture thereof
GB1095912A (en) Trans indolomorphinans and preparation thereof
GB1085135A (en) Aryl-ª‡-aminoketone derivatives
GB1073521A (en) Indole derivatives
GB1308832A (en) Pyridazine derivatives