GB976727A - Novel estradiol derivatives, processes for their preparation and pharmaceutical compositions incorporating the same - Google Patents

Novel estradiol derivatives, processes for their preparation and pharmaceutical compositions incorporating the same

Info

Publication number
GB976727A
GB976727A GB1729162A GB1729162A GB976727A GB 976727 A GB976727 A GB 976727A GB 1729162 A GB1729162 A GB 1729162A GB 1729162 A GB1729162 A GB 1729162A GB 976727 A GB976727 A GB 976727A
Authority
GB
United Kingdom
Prior art keywords
preparation
pharmaceutical compositions
same
processes
compositions incorporating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1729162A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR860746A external-priority patent/FR1368727A/en
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB976727A publication Critical patent/GB976727A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 9b -estra-1, 3, 5(10)-triene derivatives having the formula <FORM:0976727/C1/1> in which R and R1, which may be the same or different, each represents a hydrogen atom, an acyl radical derived from a carboxylic acid having 1 to 18 carbon atoms, or an alkyl group having from 1 to 6 carbon atoms, pharmaceutical compositions thereof and a process for the preparation thereof in which a 9b , 10a -19-nor-4-en-3-one derivative having the formula <FORM:0976727/C1/2> is heated in a solvent in the presence of a palladium catalyst to yield the corresponding 3-hydroxy-9b -estra-1, 3, 5(10)-triene. As catalyst there may be used palladium hydroxide on magnesia. Said compositions having oestrogenic activity may be administered enterally, parenterally or topically as tablets, pills and glossets, as sterile injectable solutions and suspensions, as suppositories, ovules and implants, and in the form of ointments. Specification 976,726 is referred to.
GB1729162A 1961-05-04 1962-05-04 Novel estradiol derivatives, processes for their preparation and pharmaceutical compositions incorporating the same Expired GB976727A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR860746A FR1368727A (en) 1961-05-04 1961-05-04 Estradiol derivatives and method of preparation
FR869787A FR1444M (en) 1961-05-04 1961-08-02 New drug especially for the treatment of ovarian irregularities and insufficiencies.

Publications (1)

Publication Number Publication Date
GB976727A true GB976727A (en) 1964-12-02

Family

ID=26190375

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1729162A Expired GB976727A (en) 1961-05-04 1962-05-04 Novel estradiol derivatives, processes for their preparation and pharmaceutical compositions incorporating the same

Country Status (5)

Country Link
BE (1) BE617259A (en)
CH (1) CH411853A (en)
ES (1) ES276968A1 (en)
GB (1) GB976727A (en)
SE (1) SE301967B (en)

Also Published As

Publication number Publication date
BE617259A (en) 1962-11-05
ES276968A1 (en) 1962-12-01
CH411853A (en) 1966-04-30
SE301967B (en) 1968-07-01

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