GB970445A - Thiophene derivatives - Google Patents

Thiophene derivatives

Info

Publication number
GB970445A
GB970445A GB39127/62A GB3912762A GB970445A GB 970445 A GB970445 A GB 970445A GB 39127/62 A GB39127/62 A GB 39127/62A GB 3912762 A GB3912762 A GB 3912762A GB 970445 A GB970445 A GB 970445A
Authority
GB
United Kingdom
Prior art keywords
group
compound
alk1
carbon atoms
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB39127/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH, Deutsche Gold und Silber Scheideanstalt filed Critical Degussa GmbH
Priority claimed from DED40401A external-priority patent/DE1199783B/en
Priority claimed from DED40471A external-priority patent/DE1219038B/en
Publication of GB970445A publication Critical patent/GB970445A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0970445/C1/1> wherein R1 is a hydroxy group or a direct link to the group Alk1, Alk1 and Alk2 are straight or branched saturated hydrocarbon chains with 2 to 4 carbon atoms, at least two carbon atoms connecting respectively the group CR1 and the group NR4 and the group NR4 and the phenyl radical, R2 and R3 are hydrogen or halogen atoms or hydroxy or alkoxy groups, and R4 is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, salts and quaternary compounds thereof, and their preparation by reaction of a compound of formula <FORM:0970445/C1/2> with 2-thienyl-lithium; or a compound of formula <FORM:0970445/C1/3> with phenyl magnesium bromide, to obtain in each case a compound of the first general formula wherein R1 is a hydroxy group and, if desired, converting this product by an acidcatalyzed dehydration to a compound of the first general formula wherein R1 is a direct link to the group Alk1. The compounds of the invention stimulate the central nervous system and dilate the coronary arteries.
GB39127/62A 1961-11-10 1962-10-16 Thiophene derivatives Expired GB970445A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DED37431A DE1194424B (en) 1961-11-10 1961-11-10 Process for the preparation of basic thiophene derivatives
DED40401A DE1199783B (en) 1962-11-30 1962-11-30 Process for the preparation of basic thiophene derivatives
DED40465A DE1213851B (en) 1961-11-10 1962-12-07 Process for the preparation of new pharmaceutically valuable thiophene compounds
DED40471A DE1219038B (en) 1962-12-08 1962-12-08 Process for the preparation of thiophene compounds

Publications (1)

Publication Number Publication Date
GB970445A true GB970445A (en) 1964-09-23

Family

ID=45560586

Family Applications (1)

Application Number Title Priority Date Filing Date
GB39127/62A Expired GB970445A (en) 1961-11-10 1962-10-16 Thiophene derivatives

Country Status (8)

Country Link
BE (1) BE628104A (en)
BR (1) BR6243797D0 (en)
CH (1) CH429760A (en)
DE (2) DE1194424B (en)
DK (2) DK105595C (en)
FI (2) FI42572C (en)
GB (1) GB970445A (en)
SE (2) SE311168B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1921453C3 (en) * 1969-04-26 1973-04-19 Degussa Basic dithienyl derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB646198A (en) * 1946-02-28 1950-11-15 Winthrop Stearns Inc Improvements in or relating to the preparation of antispasmodic agents
GB657301A (en) * 1948-02-25 1951-09-19 Wellcome Found Improvements in and relating to the preparation of substituted amino-alcohols and derivatives thereof
GB702269A (en) * 1950-01-06 1954-01-13 Wellcome Found Tertiary allylamines of therapeutic value and the production thereof

Also Published As

Publication number Publication date
SE311168B (en) 1969-06-02
FI42577B (en) 1970-06-01
DE1194424B (en) 1965-06-10
SE309601B (en) 1969-03-31
FI42577C (en) 1970-09-14
CH429760A (en) 1967-02-15
BE628104A (en) 1963-05-29
DK105595C (en) 1966-10-17
DE1213851B (en) 1966-04-07
DK105813C (en) 1966-11-14
FI42572C (en) 1970-09-14
BR6243797D0 (en) 1973-05-24
FI42572B (en) 1970-06-01

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