GB959704A - New indene derivatives and method of preparing the same - Google Patents
New indene derivatives and method of preparing the sameInfo
- Publication number
- GB959704A GB959704A GB3144361A GB3144361A GB959704A GB 959704 A GB959704 A GB 959704A GB 3144361 A GB3144361 A GB 3144361A GB 3144361 A GB3144361 A GB 3144361A GB 959704 A GB959704 A GB 959704A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- optionally substituted
- general formula
- propionic acid
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000003454 indenyl group Chemical class C1(C=CC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- PXORBAGTGTXORO-UHFFFAOYSA-N 1-phenyl-1h-indene Chemical compound C1=CC2=CC=CC=C2C1C1=CC=CC=C1 PXORBAGTGTXORO-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 2
- 230000018044 dehydration Effects 0.000 abstract 2
- 238000006297 dehydration reaction Methods 0.000 abstract 2
- -1 pyrrolidino, piperidino, morpholino Chemical group 0.000 abstract 2
- VGXMCMYXNGFQAX-UHFFFAOYSA-N 1-(4-methylphenyl)-1h-indene Chemical class C1=CC(C)=CC=C1C1C2=CC=CC=C2C=C1 VGXMCMYXNGFQAX-UHFFFAOYSA-N 0.000 abstract 1
- MRSFZLIUPQEGGE-UHFFFAOYSA-N 2-phenyl-1,3-dihydroinden-2-ol Chemical class C1C2=CC=CC=C2CC1(O)C1=CC=CC=C1 MRSFZLIUPQEGGE-UHFFFAOYSA-N 0.000 abstract 1
- ZMPPLAZKDQYBSC-UHFFFAOYSA-N 2-phenyl-2,3-dihydro-1h-inden-1-ol Chemical class C1C2=CC=CC=C2C(O)C1C1=CC=CC=C1 ZMPPLAZKDQYBSC-UHFFFAOYSA-N 0.000 abstract 1
- OZJSJMQDARKMJH-UHFFFAOYSA-N 6-chloro-2-phenyl-2,3-dihydroinden-1-one Chemical compound ClC1=CC=C2CC(C(C2=C1)=O)C1=CC=CC=C1 OZJSJMQDARKMJH-UHFFFAOYSA-N 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 abstract 1
- 229940073608 benzyl chloride Drugs 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000007937 lozenge Substances 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- SUSQOBVLVYHIEX-UHFFFAOYSA-N phenylacetonitrile Chemical compound N#CCC1=CC=CC=C1 SUSQOBVLVYHIEX-UHFFFAOYSA-N 0.000 abstract 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 abstract 1
- CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical class CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL282517D NL282517A (enrdf_load_stackoverflow) | 1961-08-31 | ||
| GB3144361A GB959704A (en) | 1961-08-31 | 1961-08-31 | New indene derivatives and method of preparing the same |
| FR69042845A FR1500757A (fr) | 1961-08-31 | 1962-08-30 | Nouveaux dérivés de l'indène et méthode de préparation de ces dérivés |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3144361A GB959704A (en) | 1961-08-31 | 1961-08-31 | New indene derivatives and method of preparing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB959704A true GB959704A (en) | 1964-06-03 |
Family
ID=10323170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3144361A Expired GB959704A (en) | 1961-08-31 | 1961-08-31 | New indene derivatives and method of preparing the same |
Country Status (3)
| Country | Link |
|---|---|
| FR (1) | FR1500757A (enrdf_load_stackoverflow) |
| GB (1) | GB959704A (enrdf_load_stackoverflow) |
| NL (1) | NL282517A (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3360435A (en) * | 1964-09-15 | 1967-12-26 | Mead Johnson & Co | Treatment of depressed states |
| US3505404A (en) * | 1965-10-01 | 1970-04-07 | Kefalas As | 3,3-dialkyl-1-phenyl-1-indanalkylamines |
| US3532752A (en) * | 1965-12-30 | 1970-10-06 | Merck & Co Inc | 1-alkylidene-3-indenyl aliphatic amines |
-
0
- NL NL282517D patent/NL282517A/xx unknown
-
1961
- 1961-08-31 GB GB3144361A patent/GB959704A/en not_active Expired
-
1962
- 1962-08-30 FR FR69042845A patent/FR1500757A/fr not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3360435A (en) * | 1964-09-15 | 1967-12-26 | Mead Johnson & Co | Treatment of depressed states |
| US3505404A (en) * | 1965-10-01 | 1970-04-07 | Kefalas As | 3,3-dialkyl-1-phenyl-1-indanalkylamines |
| US3532752A (en) * | 1965-12-30 | 1970-10-06 | Merck & Co Inc | 1-alkylidene-3-indenyl aliphatic amines |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1500757A (fr) | 1968-01-25 |
| NL282517A (enrdf_load_stackoverflow) |
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