GB953464A - Cyclic amides - Google Patents
Cyclic amidesInfo
- Publication number
- GB953464A GB953464A GB18566/60A GB1856660A GB953464A GB 953464 A GB953464 A GB 953464A GB 18566/60 A GB18566/60 A GB 18566/60A GB 1856660 A GB1856660 A GB 1856660A GB 953464 A GB953464 A GB 953464A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- benzothiadiazine
- radical
- compounds
- alkylmercaptoalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises 3, 4-dihydro-1, 2, 4-benzothiadiazine 1, 1-dioxides of the general formula: <FORM:0953464/C2/1> (wherein each of R1, R3 and R5 represents a hydrogen atom or an alkyl radical, R2 represents an unsubstituted alkylmercaptoalkyl radical, and R4 represents a halogen atom or a trihalomethyl group) and their alkali metal salts, and pharmaceutical preparations containing the foregoing compounds in admixture or conjunction with a pharmaceutically suitable carrier. The compounds may be made by reacting a compound of the general formula: <FORM:0953464/C2/2> with an aldehyde R2-CHO (or an acetal thereof), or reducing the D 2 or D 3 double bond in a corresponding 1, 2, 4-benzothiadiazine 1, 1-dioxide, and in either case, if desired, alkylating a resulting product containing a substitutable nitrogen atom and/or converting a resulting salt into the free compound or vice versa. The pharmaceutical preparations, which have diuretic, natriuretic and hypotensive activity, may be in the form of capsules, tablets, dragees, solutions, suspensions or emulsions. Specification 861,367 is referred to. Reference has been directed by the Comptroller to Specification 909,687.ALSO:3,4-Dihydro-1,2,4-benzothiadiazine 1,1-dioxides of the general formula <FORM:0953464/C3/1> (wherein each of R1, R3 and R5 represents a hydrogen atom or an alkyl radical, R2 represents an unsubstituted alkylmercaptoalkyl radical, and R4 represents a halogen atom or a trihalomethyl group) may be prepared by electrolytic reduction at the C=N bond of compounds of the general formula or <FORM:0953464/C3/2> Specification 861,367 is referred to. Reference has been directed by the Comptroller to Specification 909,687.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81526359A | 1959-05-25 | 1959-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB953464A true GB953464A (en) | 1964-03-25 |
Family
ID=25217325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB18566/60A Expired GB953464A (en) | 1959-05-25 | 1960-05-25 | Cyclic amides |
Country Status (2)
| Country | Link |
|---|---|
| CH (2) | CH387051A (en) |
| GB (1) | GB953464A (en) |
-
1960
- 1960-05-12 CH CH543260A patent/CH387051A/en unknown
- 1960-05-12 CH CH1095064A patent/CH388973A/en unknown
- 1960-05-25 GB GB18566/60A patent/GB953464A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH387051A (en) | 1965-01-31 |
| CH388973A (en) | 1965-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES318143A1 (en) | Perhydro-1,2,4-thiadiazinedioxides-(1,1) and their preparation | |
| GB1131191A (en) | New imidazole derivatives, their preparation and use | |
| GB1496787A (en) | Heteroalkylthioalkyl amidine derivatives | |
| ES289813A1 (en) | 5-phenyl-3h-1,4-benzodiazepine-2(ih)-thione and derivatives thereof | |
| GB1186863A (en) | Salts of 6-Phosphogluconic Acid and Pharmaceutical Compositions containing 6-Phosphogluconic Acid or Salts thereof | |
| GB1016071A (en) | New guanidine derivatives and process for preparing the same | |
| GB1213172A (en) | Dibenzothiazepine derivatives and production of the same | |
| GB953464A (en) | Cyclic amides | |
| GB1384219A (en) | 2-alkylamino-dihydropyridines their production and their medicinal use | |
| GB1437896A (en) | Substituted thiazole-2-carboxylic amides and process for the preparation thereof | |
| GB1144935A (en) | Anthrol derivatives and the preparation thereof | |
| ES392819A1 (en) | M-(amino-s-triazolyl)benzene-sulfonamides and their production | |
| GB1318859A (en) | Imidazo-4,5-b-pyridine derivatives | |
| ES245448A1 (en) | Improvements in or relating to novel amidines and the preparation thereof | |
| GB933968A (en) | New phthalimide derivatives | |
| GB947001A (en) | Substituted phenoxyalklylguanidines | |
| GB1032060A (en) | Novel 1h-naphtho[2,3-d]imidazole derivatives and the production thereof | |
| GB1023203A (en) | Propylamine derivatives | |
| GB1036278A (en) | Piperidine derivatives | |
| GB1085135A (en) | Aryl-ª-aminoketone derivatives | |
| GB1088395A (en) | Improvements in or relating to sulphonyl urea derivatives | |
| GB969027A (en) | Tetrahydrodibenzazocines | |
| GB1041693A (en) | Ethers of dibenzocyclohepten-10-ols | |
| GB1005728A (en) | New amino-guanidines and process for their manufacture | |
| GB999221A (en) | Cyclohexane derivatives |