GB952030A - Process for making minute capsules - Google Patents
Process for making minute capsulesInfo
- Publication number
- GB952030A GB952030A GB41353/62A GB4135362A GB952030A GB 952030 A GB952030 A GB 952030A GB 41353/62 A GB41353/62 A GB 41353/62A GB 4135362 A GB4135362 A GB 4135362A GB 952030 A GB952030 A GB 952030A
- Authority
- GB
- United Kingdom
- Prior art keywords
- millilitres
- agitation
- wall
- add
- coacervation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/20—After-treatment of capsule walls, e.g. hardening
- B01J13/206—Hardening; drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dispersion Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
952,030. Encapsulating processes. NATIONAL CASH REGISTER CO. Nov. 1, 1962 [Nov. 10, 1961], No. 41353/62. Heading B8C. Minute capsules consisting of solid or liquid water insoluble material contained within a wall of hardened hydrophilic polymeric material are formed by dispersing by agitation the core particles in an aqueous vehicle with one or more hydrophilic film forming polymeric materials, inducing coacervation to surround each core particle with a liquid wall and subsequently adding a reactant to harden the wall and render it water insoluble. Optionally the wall may afterwards be rendered less rigid by treating with a plasticizer. Coacervation may be induced by lowering the pH value or addition of a coacervating salt. As an example, droplets of trichlorotrifluoroethane are encapsulated as follows:- Introduce into a container 100 millilitres of 5% by weight aqueous solution of polyvinylimidazole and the same quantity of the same strength solution of gum arabic. Add 300 millilitres of water and adjust to a pH above 9.5 to inhibit the immediate formation of complex units. Add with agitation 25 millilitres of the liquid being encapsulated, the agitation being used to control the droplet size to, say 100, microns diameter, and adjust the pH value quickly to 6.9-7.0 to induce coacervation. Continue agitation and add a metallic chelating salt e.g. CrCl 3 or CuSO 4 to rigidify the walls. Five millilitres of CrCl 3 may be used. The capsules so formed may be plasticized by adding 40 millilitres of a 75% by weight aqueous solution of sorbitol to the vehicle.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15144961A | 1961-11-10 | 1961-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB952030A true GB952030A (en) | 1964-03-11 |
Family
ID=22538814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB41353/62A Expired GB952030A (en) | 1961-11-10 | 1962-11-01 | Process for making minute capsules |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT239201B (en) |
| BE (1) | BE624492A (en) |
| CH (1) | CH409880A (en) |
| DE (1) | DE1265130B (en) |
| DK (1) | DK107679C (en) |
| FR (1) | FR1339149A (en) |
| GB (1) | GB952030A (en) |
| NL (2) | NL129489C (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2800457A (en) * | 1953-06-30 | 1957-07-23 | Ncr Co | Oil-containing microscopic capsules and method of making them |
-
0
- BE BE624492D patent/BE624492A/xx unknown
- NL NL285331D patent/NL285331A/xx unknown
- NL NL129489D patent/NL129489C/xx active
-
1962
- 1962-11-01 GB GB41353/62A patent/GB952030A/en not_active Expired
- 1962-11-08 DE DEN22330A patent/DE1265130B/en active Pending
- 1962-11-09 CH CH1310662A patent/CH409880A/en unknown
- 1962-11-09 FR FR914864A patent/FR1339149A/en not_active Expired
- 1962-11-09 AT AT881162A patent/AT239201B/en active
- 1962-11-10 DK DK485462AA patent/DK107679C/en active
Also Published As
| Publication number | Publication date |
|---|---|
| DE1265130B (en) | 1968-04-04 |
| FR1339149A (en) | 1963-10-04 |
| AT239201B (en) | 1965-03-25 |
| DK107679C (en) | 1967-06-26 |
| NL129489C (en) | |
| NL285331A (en) | |
| BE624492A (en) | |
| CH409880A (en) | 1966-03-31 |
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