GB948860A - ªÏ-amino-2-aryl-2-pyridylalkanamide derivatives - Google Patents

ªÏ-amino-2-aryl-2-pyridylalkanamide derivatives

Info

Publication number
GB948860A
GB948860A GB18878/62A GB1887862A GB948860A GB 948860 A GB948860 A GB 948860A GB 18878/62 A GB18878/62 A GB 18878/62A GB 1887862 A GB1887862 A GB 1887862A GB 948860 A GB948860 A GB 948860A
Authority
GB
United Kingdom
Prior art keywords
pyridyl
halide
alkyl
formula
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB18878/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26808264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB948860(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of GB948860A publication Critical patent/GB948860A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises pyridyl-aminoalkanoic amides of the formula: <FORM:0948860/C2/1> wherein X is hydrogen or chlorine, Ar is a phenyl tolyl, xylyl, naphthyl, halophenyl, (e.g. chloro-fluoro-or iodo-phenyl) anisyl, dimethoxyphenyl or pyridyl radical, Alk is an ethylene or trimethylene radical and R1R2N- is a tertiary amino radical (alkyl)2 N-, wherein the alkyl group contains 3 carbon atoms, or a cyclic amino radical of the formula: <FORM:0948860/C2/2> m being 1 to 3 and n being 1 to 4; including acid addition and quaternary ammonium salts of these compounds such as the hydrohalide, sulphate, phosphate, sulphamate, citrate, lactate, maleate, malate, succinate, tartrate, cinnamate, acetate, benzoate, gluconate and ascorbate and the quaternary ammonium alkyl halide, aralkyl halide, alkyl sulphate, arylsulphonate, ethylene chlorohydrin, propylene chlorohydrin and alkenyl halide derivatives. The amides are prepared by hydration of the corresponding nitriles either with acids or bases. Pyridyl-aminoalkyl-nitriles of the formula: <FORM:0948860/C2/3> used as starting materials, are made by condensing the alkali-metal derivative of a nitrile Ar.CH2.CN with a halopyridine (optionally bearing a further chlorine substituent) and treating the resulting a -aryl-a -pyridyl-acetonitrile with an aminoalkyl halide R1R2N-alk-halogen.
GB18878/62A 1961-05-17 1962-05-16 ªÏ-amino-2-aryl-2-pyridylalkanamide derivatives Expired GB948860A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11065361A 1961-05-17 1961-05-17
US14200761A 1961-10-02 1961-10-02

Publications (1)

Publication Number Publication Date
GB948860A true GB948860A (en) 1964-02-05

Family

ID=26808264

Family Applications (1)

Application Number Title Priority Date Filing Date
GB18878/62A Expired GB948860A (en) 1961-05-17 1962-05-16 ªÏ-amino-2-aryl-2-pyridylalkanamide derivatives

Country Status (4)

Country Link
BE (1) BE617730A (en)
DE (1) DE1470216C3 (en)
FR (1) FR2485M (en)
GB (1) GB948860A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014569A2 (en) * 1979-02-02 1980-08-20 G.D. Searle & Co. (-)-Alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-2-pyridineacetamide and pharmacologically acceptable salts thereof, process for the production thereof and compositions containing the same
US4356177A (en) * 1979-10-11 1982-10-26 C.M. Industries Myocardium-protecting pyridine derivatives having an anti-arrhythmic activity and an activity as blood-platelets antiaggregants

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107205A (en) * 1977-03-11 1978-08-15 G. D. Searle & Co. α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]acetamides and related compounds
FR2471784A1 (en) * 1979-12-21 1981-06-26 Roussel Uclaf EXTENDED ACTION ANTIARRHYTHMIC DRUGS WITH THE ACTIVE INGREDIENT AS A / 2- / BIS (1-METHYLETHYL) AMINO / ETHYL / -A-PHENYL-2-PYRIDINE ACETAMIDE OR SALTS THEREOF, AND THE PROCESS FOR THE PREPARATION OF THESE MEDICAMENTS AND COMPOSITIONS INCLUDING THEM
WO1982004392A1 (en) * 1981-06-18 1982-12-23 Uclaf Roussel Method of preparing pharmaceutical compositions containing alpha-/2-/bis(1-methylethyl)amino/ethyl/alpha-phenyl 2-pyridine acetamide or one of its salts
JPS5980664A (en) * 1982-09-30 1984-05-10 Fujisawa Pharmaceut Co Ltd Alpha-aryl-alpha-pyridylfatty acid derivative and preparation thereof
US4783537A (en) * 1985-11-13 1988-11-08 Pennwalt Corporation α-(aminoalkyl)-arylacetic acid derivatives
US4847301A (en) * 1985-11-13 1989-07-11 Pennwalt Corporation Methods of use of α-(aminoalkyl)-arylacetic acid derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014569A2 (en) * 1979-02-02 1980-08-20 G.D. Searle & Co. (-)-Alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-2-pyridineacetamide and pharmacologically acceptable salts thereof, process for the production thereof and compositions containing the same
EP0014569A3 (en) * 1979-02-02 1981-03-18 G.D. Searle & Co. (-)-alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-2-pyridineacetamide and pharmacologically acceptable salts thereof, process for the production thereof and compositions containing the same
US4356177A (en) * 1979-10-11 1982-10-26 C.M. Industries Myocardium-protecting pyridine derivatives having an anti-arrhythmic activity and an activity as blood-platelets antiaggregants

Also Published As

Publication number Publication date
BE617730A (en) 1962-11-16
DE1470216C3 (en) 1974-03-28
DE1470216A1 (en) 1969-05-08
DE1470216B2 (en) 1973-08-23
FR2485M (en) 1964-04-27

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