GB948485A - New alkaloids and other new compounds from holarrhena species and processes for obtaining the same - Google Patents
New alkaloids and other new compounds from holarrhena species and processes for obtaining the sameInfo
- Publication number
- GB948485A GB948485A GB5150/60A GB515060A GB948485A GB 948485 A GB948485 A GB 948485A GB 5150/60 A GB5150/60 A GB 5150/60A GB 515060 A GB515060 A GB 515060A GB 948485 A GB948485 A GB 948485A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkaloid
- species
- amino
- alkaloids
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930013930 alkaloid Natural products 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 3
- 241000983398 Holarrhena Species 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 2
- 241001678557 Holarrhena floribunda Species 0.000 abstract 2
- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-chlorosuccinimide Chemical compound ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 abstract 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 2
- SZCHXNLVRKQEGO-XKDXWZMYSA-N alkaloid b Chemical compound C([C@@]12C=C([C@H]([C@H]2C2=C3)O)OC)CCN1C[C@H](O)C2=CC1=C3OCO1 SZCHXNLVRKQEGO-XKDXWZMYSA-N 0.000 abstract 2
- 229930002875 chlorophyll Natural products 0.000 abstract 2
- 235000019804 chlorophyll Nutrition 0.000 abstract 2
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 abstract 2
- 229920001971 elastomer Polymers 0.000 abstract 2
- 238000001704 evaporation Methods 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 2
- 239000005060 rubber Substances 0.000 abstract 2
- 230000003637 steroidlike Effects 0.000 abstract 2
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 abstract 1
- KYTDBKDWDOVRLJ-FQBRJNOBSA-N 1,2-dihydro-2,11-epoxycephalotaxine Chemical compound O1C(OC)([C@H]([C@H]2C3=C4)O)C[C@]52CCCN5CC1C3=CC1=C4OCO1 KYTDBKDWDOVRLJ-FQBRJNOBSA-N 0.000 abstract 1
- GPRZXDPWGLHIQE-QYYVTAPASA-N 1-[(3r,8s,9s,10r,13s,14s,17s)-3-amino-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl]ethanone Chemical compound C1C=C2C[C@H](N)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 GPRZXDPWGLHIQE-QYYVTAPASA-N 0.000 abstract 1
- GPRZXDPWGLHIQE-QGVNFLHTSA-N 1-[(3s,8s,9s,10r,13s,14s,17s)-3-amino-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl]ethanone Chemical compound C1C=C2C[C@@H](N)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 GPRZXDPWGLHIQE-QGVNFLHTSA-N 0.000 abstract 1
- ZTNBSFMIFOLVCM-UHFFFAOYSA-N 20S-Dimethylamino-3alpha-methoxypregn-5-ene Natural products C12CCC3(C)C(C(C)N(C)C)CCC3C2CC=C2C1(C)CCC(OC)C2 ZTNBSFMIFOLVCM-UHFFFAOYSA-N 0.000 abstract 1
- PZZXYDQKZIGACT-UHFFFAOYSA-N 5-hydroxyskytanthine Natural products C1N(C)CC(C)C2(O)C1C(C)CC2 PZZXYDQKZIGACT-UHFFFAOYSA-N 0.000 abstract 1
- MFTGIJQOGNIYMM-UHFFFAOYSA-N Monomethylholamine Natural products CNC(C)C1CCC2(C)C3CCC4(C)C(CCC4=O)C3CC=C2C1 MFTGIJQOGNIYMM-UHFFFAOYSA-N 0.000 abstract 1
- GRTOGORTSDXSFK-XJTZBENFSA-N ajmalicine Chemical compound C1=CC=C2C(CCN3C[C@@H]4[C@H](C)OC=C([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 GRTOGORTSDXSFK-XJTZBENFSA-N 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 230000009615 deamination Effects 0.000 abstract 1
- 238000006481 deamination reaction Methods 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- GPRZXDPWGLHIQE-UHFFFAOYSA-N holamine Natural products C1C=C2CC(N)CCC2(C)C2C1C1CCC(C(=O)C)C1(C)CC2 GPRZXDPWGLHIQE-UHFFFAOYSA-N 0.000 abstract 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960003671 mercuric iodide Drugs 0.000 abstract 1
- YFDLHELOZYVNJE-UHFFFAOYSA-L mercury diiodide Chemical compound I[Hg]I YFDLHELOZYVNJE-UHFFFAOYSA-L 0.000 abstract 1
- 239000012452 mother liquor Substances 0.000 abstract 1
- 125000000018 nitroso group Chemical group N(=O)* 0.000 abstract 1
- 239000003208 petroleum Substances 0.000 abstract 1
- 229960003387 progesterone Drugs 0.000 abstract 1
- 239000000186 progesterone Substances 0.000 abstract 1
- 238000009877 rendering Methods 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 229920002258 tannic acid Polymers 0.000 abstract 1
- 235000015523 tannic acid Nutrition 0.000 abstract 1
- 229940096998 ursolic acid Drugs 0.000 abstract 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU37156 | 1959-04-30 | ||
| DES66498A DE1229086B (de) | 1959-04-30 | 1959-12-31 | Verfahren zur Gewinnung von Alkaloiden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB948485A true GB948485A (en) | 1964-02-05 |
Family
ID=25995954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5150/60A Expired GB948485A (en) | 1959-04-30 | 1960-02-12 | New alkaloids and other new compounds from holarrhena species and processes for obtaining the same |
Country Status (3)
| Country | Link |
|---|---|
| FR (3) | FR466M (enrdf_load_html_response) |
| GB (1) | GB948485A (enrdf_load_html_response) |
| OA (1) | OA01014A (enrdf_load_html_response) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2515188A1 (fr) * | 1981-10-27 | 1983-04-29 | Roussel Uclaf | Nouveaux derives du 3-amino-pregn-5-ene, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
| US4740368A (en) * | 1985-12-11 | 1988-04-26 | Plevy Donald J | Amylase containing breath cleansing confection |
-
1960
- 1960-02-12 GB GB5150/60A patent/GB948485A/en not_active Expired
- 1960-08-30 FR FR837180A patent/FR466M/fr active Active
- 1960-08-30 FR FR837181A patent/FR467M/fr active Active
- 1960-08-30 FR FR837182A patent/FR468M/fr active Active
-
1964
- 1964-12-29 OA OA51117A patent/OA01014A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| OA01014A (fr) | 1968-08-07 |
| FR468M (enrdf_load_html_response) | 1961-05-02 |
| FR467M (enrdf_load_html_response) | 1961-05-02 |
| FR466M (enrdf_load_html_response) | 1961-05-02 |
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