GB946036A - Alkylthio steroids and processes for their manufacture - Google Patents
Alkylthio steroids and processes for their manufactureInfo
- Publication number
- GB946036A GB946036A GB4103/62A GB410362A GB946036A GB 946036 A GB946036 A GB 946036A GB 4103/62 A GB4103/62 A GB 4103/62A GB 410362 A GB410362 A GB 410362A GB 946036 A GB946036 A GB 946036A
- Authority
- GB
- United Kingdom
- Prior art keywords
- steroids
- dehydrogenating
- represents hydrogen
- general formula
- dehydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises steroids of the general formula: <FORM:0946036/C2/1> wherein R1 represents hydrogen or acyl, R2 represents hydrogen or methyl, R3 represents C1 to C5 alkyl, X represents H,H; H,b -OH or =O, Y represents hydrogen or fluorine, Z represents H,H or =CH2, and R2, X, Y and Z do not simultaneously represent hydrogen, and the corresponding 1,2-dehydro compounds, and the preparation thereof by reacting steroids of the general formula: <FORM:0946036/C2/2> wherein R1, R2, X, Y and Z have the above significance, with the required alkyl mercaptan, optionally dehydrogenating the product either chemically or microbiologically to form the 1,2-dehydro-steroids and, if desired, saponifying the 17-ester group or esterifying the 17-hydroxy group in the D 4- or D 1,4-product obtained. Suitable chemical dehydrogenating reagents are selenium dioxide and 2,3-dichloro-5,6-dicyanobenzoquinone, and suitable dehydrogenating micro-organisms are Bacillus sphaericus var. fusiformis, Corynebacterium simplex and Fusarium solani. The esterification may be carried out with carboxylic acids including halo-, amino-and alkylamino-substituted carboxylic acids and dicarboxylic acids, and with phosphoric and sulphuric acids.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEM47896A DE1225638B (en) | 1961-02-02 | 1961-02-02 | Process for the preparation of 7alpha-alkylthio-17alpha-methyl-testosterones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB946036A true GB946036A (en) | 1964-01-08 |
Family
ID=7306055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4103/62A Expired GB946036A (en) | 1961-02-02 | 1962-02-02 | Alkylthio steroids and processes for their manufacture |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH410932A (en) |
| DE (1) | DE1225638B (en) |
| FR (1) | FR1772M (en) |
| GB (1) | GB946036A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5030100B1 (en) * | 1967-01-21 | 1975-09-29 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2908694A (en) * | 1959-04-06 | 1959-10-13 | American Cyanamid Co | 7-substituted thio-4-androstenes |
-
1961
- 1961-02-02 DE DEM47896A patent/DE1225638B/en active Pending
- 1961-12-19 CH CH1466061A patent/CH410932A/en unknown
-
1962
- 1962-01-19 FR FR885339A patent/FR1772M/en active Active
- 1962-02-02 GB GB4103/62A patent/GB946036A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5030100B1 (en) * | 1967-01-21 | 1975-09-29 |
Also Published As
| Publication number | Publication date |
|---|---|
| CH410932A (en) | 1966-04-15 |
| FR1772M (en) | 1963-04-16 |
| DE1225638B (en) | 1966-09-29 |
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