GB943277A - Dibenz[b,f]azepines and process for their preparation - Google Patents
Dibenz[b,f]azepines and process for their preparationInfo
- Publication number
- GB943277A GB943277A GB3927060A GB3927060A GB943277A GB 943277 A GB943277 A GB 943277A GB 3927060 A GB3927060 A GB 3927060A GB 3927060 A GB3927060 A GB 3927060A GB 943277 A GB943277 A GB 943277A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- compound
- azepines
- dibenzo
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
The invention comprises compounds of the general formula: <FORM:0943277/C2/1> (wherein X and Y represent hydrogen atoms, symmetrically disposed identical halogen atoms, or symmetrically disposed methyl groups, and R represents an alkyl or alkenyl radical of at most 5 carbon atoms), and the preparation thereof by treating a compound of the general formula: <FORM:0943277/C2/2> (wherein Z represents a C1-5 alkyl or alkoxy radical) with bromine to form a dibromo compound of the general formula: <FORM:0943277/C2/3> and treating this with two molecular proportions of an alkali metal compound of an alcohol ROH to form a compound of the first general formula above, which, if desired, is hydrolysed to a compound of the second general formula, or by a modified process in which the dibromo compound is first treated with an inorganic or organic basic substance to form a monobromo compound of the general formula: <FORM:0943277/C2/4> and this is then treated with at least an equimolecular proportion of the alkali metal alcoholate. The products are useful as intermediates in the synthesis of medicaments. 5-Acetyl-5H-dibenzo[b,f]azepines of the third general formula above (in which Z=CH3) are prepared by acetylation of the corresponding 5H-dibenzo[b,f]azepines, or of their 10,11-dihydro derivatives with subsequent bromination with bromosuccinimide and splitting off of hydrogen bromide under conditions not affecting the acetyl group.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH8063459A CH383977A (en) | 1959-11-16 | 1959-11-16 | Process for the production of new azepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB943277A true GB943277A (en) | 1963-12-04 |
Family
ID=4538106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3927060A Expired GB943277A (en) | 1959-11-16 | 1960-11-16 | Dibenz[b,f]azepines and process for their preparation |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES262485A1 (en) |
| GB (1) | GB943277A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4076812A (en) * | 1974-09-27 | 1978-02-28 | Ciba-Geigy Corporation | 10-Halogeno- or 10,11-dihalogeno derivatives of 5H-dibenz[b,f]azepine |
| WO2005096709A2 (en) * | 2004-03-11 | 2005-10-20 | Sun Pharmaceutical Industries Limited | A process for the preparation of 10,11-dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide |
-
1960
- 1960-11-15 ES ES0262485A patent/ES262485A1/en not_active Expired
- 1960-11-16 GB GB3927060A patent/GB943277A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4076812A (en) * | 1974-09-27 | 1978-02-28 | Ciba-Geigy Corporation | 10-Halogeno- or 10,11-dihalogeno derivatives of 5H-dibenz[b,f]azepine |
| WO2005096709A2 (en) * | 2004-03-11 | 2005-10-20 | Sun Pharmaceutical Industries Limited | A process for the preparation of 10,11-dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide |
| WO2005096709A3 (en) * | 2004-03-11 | 2006-04-27 | Sun Pharmaceutical Ind Ltd | A process for the preparation of 10,11-dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide |
Also Published As
| Publication number | Publication date |
|---|---|
| ES262485A1 (en) | 1961-06-01 |
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