GB931115A - Pharmaceutical preparations containing sitosterols - Google Patents
Pharmaceutical preparations containing sitosterolsInfo
- Publication number
- GB931115A GB931115A GB35393/59A GB3539359A GB931115A GB 931115 A GB931115 A GB 931115A GB 35393/59 A GB35393/59 A GB 35393/59A GB 3539359 A GB3539359 A GB 3539359A GB 931115 A GB931115 A GB 931115A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sitosterol
- linoleic acid
- sitosterols
- tocopherol
- tween
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 235000015500 sitosterol Nutrition 0.000 title abstract 3
- LGJMUZUPVCAVPU-ANOYILKDSA-N (3s,8r,9s,10s,13r,14s,17r)-17-[(2r,5s)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical class C1CC2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@H](CC)C(C)C)[C@@]1(C)CC2 LGJMUZUPVCAVPU-ANOYILKDSA-N 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 229940083492 sitosterols Drugs 0.000 title abstract 2
- 229950005143 sitosterol Drugs 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 abstract 2
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 abstract 2
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 abstract 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 abstract 2
- 235000020778 linoleic acid Nutrition 0.000 abstract 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 2
- 229920000053 polysorbate 80 Polymers 0.000 abstract 2
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 abstract 2
- 229960001295 tocopherol Drugs 0.000 abstract 2
- 239000011732 tocopherol Substances 0.000 abstract 2
- KZJWDPNRJALLNS-VPUBHVLGSA-N (-)-beta-Sitosterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@@H](C(C)C)CC)C)CC4)CC3)CC=2)CC1 KZJWDPNRJALLNS-VPUBHVLGSA-N 0.000 abstract 1
- CSVWWLUMXNHWSU-UHFFFAOYSA-N (22E)-(24xi)-24-ethyl-5alpha-cholest-22-en-3beta-ol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(CC)C(C)C)C1(C)CC2 CSVWWLUMXNHWSU-UHFFFAOYSA-N 0.000 abstract 1
- KLEXDBGYSOIREE-UHFFFAOYSA-N 24xi-n-propylcholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CCC)C(C)C)C1(C)CC2 KLEXDBGYSOIREE-UHFFFAOYSA-N 0.000 abstract 1
- LPZCCMIISIBREI-MTFRKTCUSA-N Citrostadienol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4[C@H](C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C LPZCCMIISIBREI-MTFRKTCUSA-N 0.000 abstract 1
- ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 abstract 1
- RPWFJAMTCNSJKK-UHFFFAOYSA-N Dodecyl gallate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC(O)=C(O)C(O)=C1 RPWFJAMTCNSJKK-UHFFFAOYSA-N 0.000 abstract 1
- 240000006394 Sorghum bicolor Species 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 230000000879 anti-atherosclerotic effect Effects 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 229940076810 beta sitosterol Drugs 0.000 abstract 1
- MJVXAPPOFPTTCA-UHFFFAOYSA-N beta-Sistosterol Natural products CCC(CCC(C)C1CCC2C3CC=C4C(C)C(O)CCC4(C)C3CCC12C)C(C)C MJVXAPPOFPTTCA-UHFFFAOYSA-N 0.000 abstract 1
- 235000005822 corn Nutrition 0.000 abstract 1
- 239000002270 dispersing agent Substances 0.000 abstract 1
- 239000000555 dodecyl gallate Substances 0.000 abstract 1
- 229940080643 dodecyl gallate Drugs 0.000 abstract 1
- 235000010386 dodecyl gallate Nutrition 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB35393/59A GB931115A (en) | 1959-10-19 | 1959-10-19 | Pharmaceutical preparations containing sitosterols |
| FR840400A FR697M (enrdf_load_stackoverflow) | 1959-10-19 | 1960-10-05 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB35393/59A GB931115A (en) | 1959-10-19 | 1959-10-19 | Pharmaceutical preparations containing sitosterols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB931115A true GB931115A (en) | 1963-07-10 |
Family
ID=10377223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB35393/59A Expired GB931115A (en) | 1959-10-19 | 1959-10-19 | Pharmaceutical preparations containing sitosterols |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR697M (enrdf_load_stackoverflow) |
| GB (1) | GB931115A (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991001139A1 (de) * | 1989-07-21 | 1991-02-07 | Marigen S.A. | Sterole, deren fettsäureester und glucoside; verfahren zu ihrer herstellung; spontan dispergierbare mittel mit diesen verbindungen, sowie ihre verwendung zur behandlung von tumoren |
| EP0839458A1 (en) * | 1996-11-05 | 1998-05-06 | Riken Vitamin Co., Ltd. | Phytosterol compositions and their production |
| DE19750453A1 (de) * | 1997-11-14 | 1999-05-27 | Henkel Kgaa | Verwendung von Wirkstoffmischungen zur Herstellung von hypocholesterinämischen Mitteln |
| US6190720B1 (en) * | 1999-06-15 | 2001-02-20 | Opta Food Ingredients, Inc. | Dispersible sterol compositions |
| US6677327B1 (en) | 1999-11-24 | 2004-01-13 | Archer-Daniels-Midland Company | Phytosterol and phytostanol compositions |
-
1959
- 1959-10-19 GB GB35393/59A patent/GB931115A/en not_active Expired
-
1960
- 1960-10-05 FR FR840400A patent/FR697M/fr active Active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991001139A1 (de) * | 1989-07-21 | 1991-02-07 | Marigen S.A. | Sterole, deren fettsäureester und glucoside; verfahren zu ihrer herstellung; spontan dispergierbare mittel mit diesen verbindungen, sowie ihre verwendung zur behandlung von tumoren |
| US5270041A (en) * | 1989-07-21 | 1993-12-14 | Marigen S.A. | Sterols, their fatty acid esters and glucosides; processes for their preparation; spontaneously dispersible agents containing these compounds, and their use for treatment of tumors |
| EP0839458A1 (en) * | 1996-11-05 | 1998-05-06 | Riken Vitamin Co., Ltd. | Phytosterol compositions and their production |
| US5998396A (en) * | 1996-11-05 | 1999-12-07 | Riken Vitamin Co., Ltd. | Oil solubilized solutions and foods containing phytosterols and process for their production |
| DE19750453A1 (de) * | 1997-11-14 | 1999-05-27 | Henkel Kgaa | Verwendung von Wirkstoffmischungen zur Herstellung von hypocholesterinämischen Mitteln |
| US6190720B1 (en) * | 1999-06-15 | 2001-02-20 | Opta Food Ingredients, Inc. | Dispersible sterol compositions |
| US6677327B1 (en) | 1999-11-24 | 2004-01-13 | Archer-Daniels-Midland Company | Phytosterol and phytostanol compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| FR697M (enrdf_load_stackoverflow) | 1961-07-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS56135416A (en) | Pharmaceutical preparation for skin | |
| JPH0140002B2 (enrdf_load_stackoverflow) | ||
| IE800406L (en) | Pharmaceutical composition | |
| Kraml et al. | GASTROINTESTINAL ABSORPTION OF GRISEOFULVIN: I. EFFECT OF PARTICLE SIZE, ADDITION OF SURFACTANTS, AND CORN OIL ON THE LEVEL OF GRISEOFULVIN IN THE SERUM OF RATS | |
| GB931115A (en) | Pharmaceutical preparations containing sitosterols | |
| EP0004898B1 (de) | Feste stabile pharmazeutische Zusammensetzung auf Basis von einem 1,3-Diester des 17-alpha-Ethinyl-7-alpha-methyl-1,3,5(10)-östratrien-1,3,17-beta-triols | |
| JPH03275613A (ja) | 皮膚外用剤 | |
| GB543309A (en) | Improvements in or relating to drugs | |
| GB1130566A (en) | Dentifrice | |
| ES8507110A1 (es) | Procedimiento para la preparacion de derivados del acido indolacetico | |
| GAUL | Sensitivity to bithionol | |
| GB996207A (en) | Improved vitamin a compositions | |
| Rudzki et al. | Dermatitis from retinoic acid. | |
| IE43994L (en) | Diphenylmethanes. | |
| GB1065910A (en) | Purified extracts of gleditsia species and compositions thereof | |
| PATTERSON et al. | Preputial gland beta-glucuronidase response to testosterone and to two anabolic steroids | |
| JPH1046142A (ja) | 抗酸化剤 | |
| Fieser et al. | Naphthoquinone oxides | |
| JPS6017770B2 (ja) | 動物肥育用組成物 | |
| GB713720A (en) | Improvements in or relating to the preparation of stabilized liquid catalase | |
| US3899591A (en) | Preparation for treating psoriasis | |
| JPH01179678A (ja) | 抗酸化剤 | |
| CN116650399A (zh) | 一种夫西地酸乳膏及其制备方法 | |
| GB922442A (en) | Steroids | |
| AU246930B2 (en) | Improvements in or relating to processes forthe preparation of amidophosphoryl compounds and of compositions comprising these compounds for combating noxious organisms |