GB926591A - Improvements in or relating to antibiotics - Google Patents

Improvements in or relating to antibiotics

Info

Publication number
GB926591A
GB926591A GB32811/60A GB3281160A GB926591A GB 926591 A GB926591 A GB 926591A GB 32811/60 A GB32811/60 A GB 32811/60A GB 3281160 A GB3281160 A GB 3281160A GB 926591 A GB926591 A GB 926591A
Authority
GB
United Kingdom
Prior art keywords
antibiotic
venturicidin
mycelium
butanol
chloroform
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32811/60A
Inventor
Alan Rhodes
Brian Boothroyd
Karl Heinz Fantes
Moira Patricia Mcgonagle
Roger Crosse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to GB32811/60A priority Critical patent/GB926591A/en
Priority to DK376061AA priority patent/DK102902C/en
Publication of GB926591A publication Critical patent/GB926591A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

<PICT:0926591/IV(a)/1> Relates to a new antibiotic AA368, alternatively designated Venturicidin, which has the elementary analysis C 64.89%, H 8.95% and N 1.75%, a specific rotation of [a ]20D + 114 DEG (c, 1% in chloroform) and which is soluble in butanol, ethyl acetate and chloroform, has an ultra-violet spectrum showing peaks at 280mm and 200mm , an infra-red absorption spectrum as shown and a melting point (uncorrected) of 140-142 DEG C. following recrystallization from ethyl acetate/petroleum ether (1:3 by volume). The antibiotic may be produced by culturing an AA368-producing species of the genus streptomyces, such as Streptomyces NCIB 9198, 9199 or 9200, on or in a nutrient medium therefor under aerobic conditions and thereafter recovering the antibiotic thus produced from the culture broth, e.g. by filtering the mycelium from the broth and extracting the antibiotic from the mycelium with an organic solvent therefor, such as acetone, butanol, and ethyl, butyl or amyl acetate.ALSO:Fungicidal compositions comprise aqueous solutions containing antibiotic AA368, alternatively designated Venturicidin (see Group IV (b)), ethylene glycol monoethyl ether and a non-ionic surface-active agent with octyl phenol as hydrophobic group in combination with a polyoxyethylene chain.
GB32811/60A 1960-09-23 1960-09-23 Improvements in or relating to antibiotics Expired GB926591A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB32811/60A GB926591A (en) 1960-09-23 1960-09-23 Improvements in or relating to antibiotics
DK376061AA DK102902C (en) 1960-09-23 1961-09-22 Process for the preparation of an antibiotic substance AA368.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB32811/60A GB926591A (en) 1960-09-23 1960-09-23 Improvements in or relating to antibiotics

Publications (1)

Publication Number Publication Date
GB926591A true GB926591A (en) 1963-05-22

Family

ID=10344352

Family Applications (1)

Application Number Title Priority Date Filing Date
GB32811/60A Expired GB926591A (en) 1960-09-23 1960-09-23 Improvements in or relating to antibiotics

Country Status (2)

Country Link
DK (1) DK102902C (en)
GB (1) GB926591A (en)

Also Published As

Publication number Publication date
DK102902C (en) 1965-10-25

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