GB1154133A - Improvements in and relating to Antibiotics. - Google Patents
Improvements in and relating to Antibiotics.Info
- Publication number
- GB1154133A GB1154133A GB6783/68A GB678368A GB1154133A GB 1154133 A GB1154133 A GB 1154133A GB 6783/68 A GB6783/68 A GB 6783/68A GB 678368 A GB678368 A GB 678368A GB 1154133 A GB1154133 A GB 1154133A
- Authority
- GB
- United Kingdom
- Prior art keywords
- helicocerin
- helicoceras
- ethyl acetate
- solvent
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,154,133. Helicocerin. SANKYO CO. Ltd. 12 Feb., 1968 [10 Feb., 1967], No. 6783/68. Heading C2A. The invention comprises an antibiotic Helicocerin, which is effective against yeasts, fungi and mycobacteria, which is soluble in methanol, ethanol, n-butanol, acetone, chloroform &c., but sparingly soluble in petroleum ether, nhexane and cyclohexane and insoluble in water; elementary analysis 64À36% C, 7À73% H and 6À43% N; empirical formula C 12 H 17 O 3 N; molecular weight 229À2; m.pt. 89-90‹ C.; No U-V spectrum; and IR-spectrum as in the figure. Hellicocerin is produced by the aerobic cultivation of a helicocerin-producing strain of Helicoceras oryzae, e.g. strain NI 4288 (Japanese Federation of Culture Collections), Helicoceras celtidis, Helicoceras plantaginis and Helicoceras nymphaerum. The clarified broth is extracted with a water-immiscible solvent such as methylene chloride, ethyl acetate, benzene, chloroform or carbon tetrachloride. After removing the solvent, the residue is treated with ethyl acetate and the extract is chromatographed on silica gel using ethyl acetate as eluant. After removal of solvent, the residue is dissolved in hot n-hexane and allowed to crystallize therefrom. A pharmaceutical composition comprises the antibiotic, helicocerin, and a carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP858867 | 1967-02-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1154133A true GB1154133A (en) | 1969-06-04 |
Family
ID=11697140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB6783/68A Expired GB1154133A (en) | 1967-02-10 | 1968-02-12 | Improvements in and relating to Antibiotics. |
Country Status (5)
Country | Link |
---|---|
DE (1) | DE1667916A1 (en) |
DK (1) | DK116429B (en) |
FR (1) | FR1573927A (en) |
GB (1) | GB1154133A (en) |
NL (1) | NL6801732A (en) |
-
1968
- 1968-02-07 NL NL6801732A patent/NL6801732A/xx unknown
- 1968-02-08 FR FR1573927D patent/FR1573927A/fr not_active Expired
- 1968-02-08 DE DE19681667916 patent/DE1667916A1/en active Pending
- 1968-02-09 DK DK50968AA patent/DK116429B/en unknown
- 1968-02-12 GB GB6783/68A patent/GB1154133A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NL6801732A (en) | 1968-08-12 |
DE1667916A1 (en) | 1971-02-25 |
DK116429B (en) | 1970-01-12 |
FR1573927A (en) | 1969-07-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1021403A (en) | Novel antibiotics and processes for their manufacture | |
GB1162027A (en) | Antibiotic SL 2266 | |
GB1339032A (en) | Rabelomycin and processes for its production | |
GB1349633A (en) | Antifungal agents | |
Balan et al. | Antiprotozoal Antibiotics. II Isolation and Characterization of Trypacidin, A New Antibiotic, Active Against Trypanosoma Cruzi and Toxoplasma Gondii | |
GB1357538A (en) | New antibiotic | |
GB1154133A (en) | Improvements in and relating to Antibiotics. | |
GB1430885A (en) | Process for preparing a purified extract of quillaia bark | |
Kettner et al. | Dactylarin, a new antiprotozoal antibiotic from Dactylaria lutea | |
SE328254B (en) | ||
GB1159970A (en) | The Antibiotic Steffisburgensimycin | |
GB980346A (en) | Improvements in or relating to novel antibiotics and the manufacture thereof | |
GB1028921A (en) | New antibiotic | |
Kato et al. | PRODUCTION, ISOLATION AND PURIFICATION OF ANTITUMOR ACTIVE MONOGLYCERIDES AND OTHER ANTIBIOTICS FROM SEPEDONIUM AMPULLOSPORUM STUDIES ON ANTIVIRAL AND ANTITUMOR ANTIBIOTICS. IX | |
GB1226665A (en) | ||
GB1139041A (en) | Chlorflavonin | |
IL42700A (en) | Antibiotic g-52 and method for the production thereof | |
ES465948A1 (en) | Fermentation process for the production of (+)-2-(5 beta -n-butyl-4 beta -hydroxy-2-oxo-tetrahydrofuran-3 beta -yl)-2 alpha -methylacetic acid | |
Gosse et al. | Novel triterpenes from alstonia boonei and anthocleista nobius | |
GB1229297A (en) | ||
GB1389065A (en) | Process for isolating an antibiotic with both antiprotozoan and cancerostatic activities | |
GB1452457A (en) | Microbiological production of biologically active 8,8-bi-1h- naphthol-2,3-c-pyrans | |
GB850325A (en) | Production of a new antibiotic flavensomycin | |
GB1212741A (en) | A method for producing an antibiotic b-2847 | |
GB1184422A (en) | Antibiotic Granaticin B and Process for its Manufacture |