GB1389065A - Process for isolating an antibiotic with both antiprotozoan and cancerostatic activities - Google Patents
Process for isolating an antibiotic with both antiprotozoan and cancerostatic activitiesInfo
- Publication number
- GB1389065A GB1389065A GB1169472A GB1169472A GB1389065A GB 1389065 A GB1389065 A GB 1389065A GB 1169472 A GB1169472 A GB 1169472A GB 1169472 A GB1169472 A GB 1169472A GB 1389065 A GB1389065 A GB 1389065A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ethyl acetate
- extracting
- antibiotic
- dactylaria
- lutea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
1389065 Antibiotic from Dactylaria lutea CESKOSLOVENSKA AKADEMIE VEB 13 March 1972 [17 March 1971] 11694/72 Heading C2A A novel antibiotic having antiprotozoal and cytostatic activity, which is characterized as being a weakly acidic substance crystallizing in the form of orange plates; having a molecular weight of 304; an empirical formula C 16 H 16 O 6 , being soluble in water, methanol and ethanol and insoluble in petroleum ether, benzene and hexane; having U.V. absorption maxima at 218, 266, 288 and 424 mÁ. in ethyl acetate, and the following I.R. absorption peaks (in KBr): 3510, 3460, 2980, 2930, 2860, 1645, 1630, 1583, 1475, 1371, 1228, 1280, 1267, 1200, 1165, 1120, 1078, 1045, 1020, 860 and 780 cm.<SP>-1</SP>, is produced by aerobically cultivating Dactylaria lutea, Routien, extracting the filtered culture with acidified ethyl acetate, extracting the organic phase with aqueous alkali, acidifying the aqueous extract and re-extracting with ethyl acetate. The extract is then evaporated to dryness and the residue is chromatographed as silica gel with chloroform/ethyl acetate, the eluate evaporated and the residue is crystallised from butanol to give the pure product.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS193571A CS154404B1 (en) | 1971-03-17 | 1971-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1389065A true GB1389065A (en) | 1975-04-03 |
Family
ID=5354975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1169472A Expired GB1389065A (en) | 1971-03-17 | 1972-03-13 | Process for isolating an antibiotic with both antiprotozoan and cancerostatic activities |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH572521A5 (en) |
| CS (1) | CS154404B1 (en) |
| DE (1) | DE2211299C3 (en) |
| GB (1) | GB1389065A (en) |
-
1971
- 1971-03-17 CS CS193571A patent/CS154404B1/cs unknown
-
1972
- 1972-03-09 DE DE19722211299 patent/DE2211299C3/en not_active Expired
- 1972-03-10 CH CH358772A patent/CH572521A5/xx not_active IP Right Cessation
- 1972-03-13 GB GB1169472A patent/GB1389065A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH572521A5 (en) | 1976-02-13 |
| DE2211299A1 (en) | 1972-09-28 |
| DE2211299B2 (en) | 1975-05-07 |
| CS154404B1 (en) | 1974-04-30 |
| DE2211299C3 (en) | 1975-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |