GB916789A - Therapeutic resin complexes - Google Patents
Therapeutic resin complexesInfo
- Publication number
 - GB916789A GB916789A GB10299/59A GB1029959A GB916789A GB 916789 A GB916789 A GB 916789A GB 10299/59 A GB10299/59 A GB 10299/59A GB 1029959 A GB1029959 A GB 1029959A GB 916789 A GB916789 A GB 916789A
 - Authority
 - GB
 - United Kingdom
 - Prior art keywords
 - phenyl
 - prepared
 - nitropropane
 - methyl
 - hydroxy
 - Prior art date
 - Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
 - Expired
 
Links
- 239000011347 resin Substances 0.000 title abstract 7
 - 229920005989 resin Polymers 0.000 title abstract 7
 - 230000001225 therapeutic effect Effects 0.000 title abstract 2
 - FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 8
 - 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
 - NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 5
 - 239000003729 cation exchange resin Substances 0.000 abstract 5
 - BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 5
 - HZYOZOFLFAXDFR-UHFFFAOYSA-N 2-methyl-2-nitro-1-phenylpropan-1-ol Chemical compound [O-][N+](=O)C(C)(C)C(O)C1=CC=CC=C1 HZYOZOFLFAXDFR-UHFFFAOYSA-N 0.000 abstract 4
 - 229920002125 Sokalan® Polymers 0.000 abstract 4
 - 150000001412 amines Chemical class 0.000 abstract 4
 - HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 4
 - -1 3,4-methylenedioxy group Chemical group 0.000 abstract 3
 - QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
 - 229910052739 hydrogen Inorganic materials 0.000 abstract 3
 - 239000001257 hydrogen Substances 0.000 abstract 3
 - 239000000203 mixture Substances 0.000 abstract 3
 - ABRWESLGGMHKEA-UHFFFAOYSA-N n-tert-butylaniline Chemical compound CC(C)(C)NC1=CC=CC=C1 ABRWESLGGMHKEA-UHFFFAOYSA-N 0.000 abstract 3
 - QYCHNFIOUYTIEC-UHFFFAOYSA-N (1-chloro-2-methyl-2-nitropropyl)benzene Chemical compound [O-][N+](=O)C(C)(C)C(Cl)C1=CC=CC=C1 QYCHNFIOUYTIEC-UHFFFAOYSA-N 0.000 abstract 2
 - 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
 - QFTWUVJQXPFWNM-UHFFFAOYSA-N 2-amino-2-methyl-1-phenylpropan-1-ol Chemical compound CC(C)(N)C(O)C1=CC=CC=C1 QFTWUVJQXPFWNM-UHFFFAOYSA-N 0.000 abstract 2
 - FGLBSLMDCBOPQK-UHFFFAOYSA-N 2-nitropropane Chemical compound CC(C)[N+]([O-])=O FGLBSLMDCBOPQK-UHFFFAOYSA-N 0.000 abstract 2
 - VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
 - 125000002877 alkyl aryl group Chemical group 0.000 abstract 2
 - 150000001450 anions Chemical class 0.000 abstract 2
 - 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
 - 125000003118 aryl group Chemical group 0.000 abstract 2
 - 150000001555 benzenes Chemical class 0.000 abstract 2
 - 229910052736 halogen Chemical group 0.000 abstract 2
 - 150000002367 halogens Chemical group 0.000 abstract 2
 - 150000002431 hydrogen Chemical class 0.000 abstract 2
 - 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
 - 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
 - MTEWAFVECQBILW-UHFFFAOYSA-N n-tert-butylcyclohexanamine Chemical compound CC(C)(C)NC1CCCCC1 MTEWAFVECQBILW-UHFFFAOYSA-N 0.000 abstract 2
 - QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 2
 - 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
 - OJTKLJUNTHGXRY-UHFFFAOYSA-N (2-methyl-2-nitropropyl)benzene Chemical compound [O-][N+](=O)C(C)(C)CC1=CC=CC=C1 OJTKLJUNTHGXRY-UHFFFAOYSA-N 0.000 abstract 1
 - LKMXYTFESDLNMI-UHFFFAOYSA-N 1-(3-aminophenyl)-2-methyl-2-nitropropan-1-ol Chemical class [O-][N+](=O)C(C)(C)C(O)C1=CC=CC(N)=C1 LKMXYTFESDLNMI-UHFFFAOYSA-N 0.000 abstract 1
 - FHHDYPZTOJAZGX-UHFFFAOYSA-N 1-chloro-2-methyl-1-phenylpropan-2-amine Chemical compound CC(C)(N)C(Cl)C1=CC=CC=C1 FHHDYPZTOJAZGX-UHFFFAOYSA-N 0.000 abstract 1
 - DVCNIIFQWVIZDA-UHFFFAOYSA-N 2,2-bis(methylamino)-1-phenylethanol Chemical compound C1(=CC=CC=C1)C(C(NC)NC)O DVCNIIFQWVIZDA-UHFFFAOYSA-N 0.000 abstract 1
 - FHWZAIWJHOEIFH-UHFFFAOYSA-N 2-chloro-1-N,1-N'-dimethyl-2-phenylethane-1,1-diamine Chemical compound C1(=CC=CC=C1)C(C(NC)NC)Cl FHWZAIWJHOEIFH-UHFFFAOYSA-N 0.000 abstract 1
 - OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
 - 241000790917 Dioxys <bee> Species 0.000 abstract 1
 - KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 1
 - OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
 - 239000007868 Raney catalyst Substances 0.000 abstract 1
 - NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
 - 229910000564 Raney nickel Inorganic materials 0.000 abstract 1
 - HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
 - KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 abstract 1
 - 229940073608 benzyl chloride Drugs 0.000 abstract 1
 - 229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
 - 239000002775 capsule Substances 0.000 abstract 1
 - 239000003054 catalyst Substances 0.000 abstract 1
 - 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
 - 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
 - 239000003937 drug carrier Substances 0.000 abstract 1
 - XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
 - 238000004519 manufacturing process Methods 0.000 abstract 1
 - FAQBDCPZTMJQOP-UHFFFAOYSA-N n-tert-butylcyclopentanamine Chemical compound CC(C)(C)NC1CCCC1 FAQBDCPZTMJQOP-UHFFFAOYSA-N 0.000 abstract 1
 - 150000002828 nitro derivatives Chemical class 0.000 abstract 1
 - MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 abstract 1
 - 239000002245 particle Substances 0.000 abstract 1
 - 239000006187 pill Substances 0.000 abstract 1
 - 229910003446 platinum oxide Inorganic materials 0.000 abstract 1
 - 229920006395 saturated elastomer Polymers 0.000 abstract 1
 - 239000003826 tablet Substances 0.000 abstract 1
 - 239000011701 zinc Substances 0.000 abstract 1
 - 229910052725 zinc Inorganic materials 0.000 abstract 1
 
Classifications
- 
        
- C—CHEMISTRY; METALLURGY
 - C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
 - C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
 - C08F8/00—Chemical modification by after-treatment
 - C08F8/34—Introducing sulfur atoms or sulfur-containing groups
 
 - 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
 - A61K31/00—Medicinal preparations containing organic active ingredients
 - A61K31/13—Amines
 - A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
 
 - 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
 - A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
 
 - 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
 - A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
 - A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
 - A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
 - A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
 - A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
 - A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
 
 - 
        
- C—CHEMISTRY; METALLURGY
 - C07—ORGANIC CHEMISTRY
 - C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
 - C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
 - C07C205/01—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms
 - C07C205/03—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
 - C07C205/04—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
 
 - 
        
- C—CHEMISTRY; METALLURGY
 - C07—ORGANIC CHEMISTRY
 - C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
 - C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
 - C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
 - C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
 - C07C205/09—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
 
 - 
        
- C—CHEMISTRY; METALLURGY
 - C07—ORGANIC CHEMISTRY
 - C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
 - C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
 - C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
 - C07C205/14—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to acyclic carbon atoms
 - C07C205/16—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
 
 - 
        
- C—CHEMISTRY; METALLURGY
 - C07—ORGANIC CHEMISTRY
 - C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
 - C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
 - C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
 
 - 
        
- C—CHEMISTRY; METALLURGY
 - C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
 - C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
 - C08F8/00—Chemical modification by after-treatment
 - C08F8/44—Preparation of metal salts or ammonium salts
 
 
Landscapes
- Chemical & Material Sciences (AREA)
 - Organic Chemistry (AREA)
 - Health & Medical Sciences (AREA)
 - Medicinal Chemistry (AREA)
 - Epidemiology (AREA)
 - Public Health (AREA)
 - Chemical Kinetics & Catalysis (AREA)
 - Pharmacology & Pharmacy (AREA)
 - Veterinary Medicine (AREA)
 - Life Sciences & Earth Sciences (AREA)
 - Animal Behavior & Ethology (AREA)
 - General Health & Medical Sciences (AREA)
 - General Chemical & Material Sciences (AREA)
 - Polymers & Plastics (AREA)
 - Engineering & Computer Science (AREA)
 - Bioinformatics & Cheminformatics (AREA)
 - Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
 - Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
 
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title | 
|---|---|---|---|
| US726010A US2990332A (en) | 1958-04-02 | 1958-04-02 | Pharmaceutical preparations comprising cation exchange resin adsorption compounds and treatment therewith | 
| US753093A US3084099A (en) | 1958-08-04 | 1958-08-04 | Therapeutic amine-resin complex composition and method of using same | 
Publications (1)
| Publication Number | Publication Date | 
|---|---|
| GB916789A true GB916789A (en) | 1963-01-30 | 
Family
ID=27111252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date | 
|---|---|---|---|
| GB10299/59A Expired GB916789A (en) | 1958-04-02 | 1959-03-25 | Therapeutic resin complexes | 
Country Status (6)
| Country | Link | 
|---|---|
| BE (1) | BE577279A (en:Method) | 
| CH (1) | CH391186A (en:Method) | 
| DK (1) | DK104116C (en:Method) | 
| FR (1) | FR465M (en:Method) | 
| GB (1) | GB916789A (en:Method) | 
| NL (2) | NL128079C (en:Method) | 
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| FR2332990A1 (fr) * | 1975-11-27 | 1977-06-24 | Nicholas Ind Ltd | Preparation de derives d'ethylamine | 
| EP0356035A3 (en) * | 1988-08-12 | 1991-04-03 | Astra Aktiebolag | Arylkalkyl-amines and -amides having anticonvulsant and neuroprotective properties | 
- 
        0
        
- NL NL237722D patent/NL237722A/xx unknown
 - NL NL128079D patent/NL128079C/xx active
 
 - 
        1959
        
- 1959-03-25 GB GB10299/59A patent/GB916789A/en not_active Expired
 - 1959-04-01 BE BE577279A patent/BE577279A/fr unknown
 - 1959-04-02 DK DK115259AA patent/DK104116C/da active
 - 1959-04-02 CH CH7151159A patent/CH391186A/de unknown
 
 - 
        1960
        
- 1960-08-30 FR FR837135A patent/FR465M/fr active Active
 
 
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| FR2332990A1 (fr) * | 1975-11-27 | 1977-06-24 | Nicholas Ind Ltd | Preparation de derives d'ethylamine | 
| EP0356035A3 (en) * | 1988-08-12 | 1991-04-03 | Astra Aktiebolag | Arylkalkyl-amines and -amides having anticonvulsant and neuroprotective properties | 
| WO1991011995A1 (en) * | 1988-08-12 | 1991-08-22 | Fisons Corporation | Arylalkyl-amines and -amides having anticonvulsant and neuroprotective properties | 
| AU654802B2 (en) * | 1988-08-12 | 1994-11-24 | Astra Aktiebolag | Arylalkyl-amines and -amides having anticonvulsant and neuroprotective properties | 
Also Published As
| Publication number | Publication date | 
|---|---|
| FR465M (en:Method) | 1961-05-02 | 
| DK104116C (da) | 1966-04-04 | 
| CH391186A (de) | 1965-04-30 | 
| NL237722A (en:Method) | |
| NL128079C (en:Method) | |
| BE577279A (fr) | 1959-10-01 | 
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