GB916139A - Quinazolone derivatives - Google Patents

Quinazolone derivatives

Info

Publication number
GB916139A
GB916139A GB8625/61A GB862561A GB916139A GB 916139 A GB916139 A GB 916139A GB 8625/61 A GB8625/61 A GB 8625/61A GB 862561 A GB862561 A GB 862561A GB 916139 A GB916139 A GB 916139A
Authority
GB
United Kingdom
Prior art keywords
compounds
acetamido
carbon atoms
general formula
resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8625/61A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Filter Wallace and Tiernan Inc
Original Assignee
Wallace and Tiernan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallace and Tiernan Inc filed Critical Wallace and Tiernan Inc
Publication of GB916139A publication Critical patent/GB916139A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Resin-drug complexes are formed by salt formation and adsorption on sulphonic or carboxylic acid cation exchange resins of heterocyclic bases of general formula <FORM:0916139/IV(a)/1> in which R and R1 represent hydrogen or alkyl with up to 5 carbon atoms. These complexes are formed, for example, by treating a suspension of the resin in distilled water with the base.ALSO:The invention comprises compounds of general formula <FORM:0916139/IV (b)/1> in which R and R1 are hydrogen or alkyl containing up to five carbon atoms, and pharmaceutically acceptable salts thereof including salts with cation exchange resins (see Group IV(a)). The compounds are prepared by reduction of the corresponding 6-nitro compounds, which are prepared by condensation of the appropriately substituted aniline with the appropriately substituted 2 - alkanamido-5-nitrobenzoic acids. 2 - Acetamido - 5 - nitrobenzoic acid is obtained by oxidation of 2-acetamido-5-nitrotoluene. The compounds possess muscle relaxing and antispasmodic properties, and may be administered alone or with a carrier suitable for oral or parenteral administration to human beings or animals, e.g. as tablets, capsules, elixirs, syrups or suspensions.
GB8625/61A 1960-03-09 1961-03-09 Quinazolone derivatives Expired GB916139A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1369160A 1960-03-09 1960-03-09

Publications (1)

Publication Number Publication Date
GB916139A true GB916139A (en) 1963-01-23

Family

ID=21761215

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8625/61A Expired GB916139A (en) 1960-03-09 1961-03-09 Quinazolone derivatives

Country Status (2)

Country Link
BE (1) BE701871A (en)
GB (1) GB916139A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3414573A (en) * 1962-06-27 1968-12-03 Squibb & Sons Inc Certain 3-alkylphenyl-quinazolones

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3414573A (en) * 1962-06-27 1968-12-03 Squibb & Sons Inc Certain 3-alkylphenyl-quinazolones

Also Published As

Publication number Publication date
BE701871A (en) 1968-01-02

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