GB910218A - New yohimbane derivatives and their preparation - Google Patents

New yohimbane derivatives and their preparation

Info

Publication number
GB910218A
GB910218A GB2693961A GB2693961A GB910218A GB 910218 A GB910218 A GB 910218A GB 2693961 A GB2693961 A GB 2693961A GB 2693961 A GB2693961 A GB 2693961A GB 910218 A GB910218 A GB 910218A
Authority
GB
United Kingdom
Prior art keywords
preparation
new
formula
yohimbane
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2693961A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB910218A publication Critical patent/GB910218A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D459/00—Heterocyclic compounds containing benz [g] indolo [2, 3-a] quinolizine ring systems, e.g. yohimbine; 16, 18-lactones thereof, e.g. reserpic acid lactone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the formula:- <FORM:0910218/IV (b)/1> (in which R1 represents a halogen atom or an alkoxy group and R2 represents a hydrogen atom or an acyl group) salts thereof, and a process for their preparation by subjecting a lactone of formula:- <FORM:0910218/IV (b)/2> to isobutanolysis, preferably with isobutanol in the presence of sodium isobutylate, and if required esterifying the 18b -hydroxy group of the resulting isobutyl ester, e.g. with a 3,4,5-trimethoxybenzoic, 3,4,5-trimethoxycinnamic, or syringic acid derivative, preferably in the presence of pyridine and triethylamine.
GB2693961A 1960-08-08 1961-07-25 New yohimbane derivatives and their preparation Expired GB910218A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR835291A FR1365954A (en) 1960-08-08 1960-08-08 New derivatives of yohimbane

Publications (1)

Publication Number Publication Date
GB910218A true GB910218A (en) 1962-11-14

Family

ID=8737088

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2693961A Expired GB910218A (en) 1960-08-08 1961-07-25 New yohimbane derivatives and their preparation

Country Status (4)

Country Link
CH (1) CH404679A (en)
FR (1) FR1365954A (en)
GB (1) GB910218A (en)
NL (1) NL6512991A (en)

Also Published As

Publication number Publication date
CH404679A (en) 1965-12-31
NL6512991A (en) 1965-12-27
FR1365954A (en) 1964-07-10

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