GB904301A - A composite vaccine for the immunization of dogs and foxes against distemper and hepatitis contagiosa canis - Google Patents

A composite vaccine for the immunization of dogs and foxes against distemper and hepatitis contagiosa canis

Info

Publication number
GB904301A
GB904301A GB2644659A GB2644659A GB904301A GB 904301 A GB904301 A GB 904301A GB 2644659 A GB2644659 A GB 2644659A GB 2644659 A GB2644659 A GB 2644659A GB 904301 A GB904301 A GB 904301A
Authority
GB
United Kingdom
Prior art keywords
aqueous
virus
distemper
dogs
formaldehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2644659A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of GB904301A publication Critical patent/GB904301A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/175—Canine distemper virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A composite vaccine for the immunization of dogs or foxes against distemper and Hepatitis contagiosa canis (H.C.C.) is prepared by mixing an aqueous suspension of an apathogenic distemper virus obtained from developing thick embryos with an aqueous suspension of H.C.C. virus which has been isolated from the liver and/or spleen of dogs or from tissue cultures and has been inactivated with an excess of formaldehyde, the excess of formaldehyde being chemically bound after inactivation of the virus by adding 1 1/2 to 2 times the stoichiometric quantity of an acid salt of sulphurous acid especially sodium bisulphite. The vaccine contains (a) 50% of the distemper component consisting of 50% chlorio-allantoic material containing distemper virus, 40% beef nutrient broth of pH 7.6 and 10% aqueous glucose and (b) 50% H.C.C. component preferably consisting of 75% aqueous suspension of inactivated H.C.C. virus and 25% aqueous aluminium hydroxide suspension. The chlorio-allantoic membranes of chick eggs are inoculated with a 4% aqueous suspension of a modified distemper virus in aqueous phosphate buffer of pH 7.6, incubated 5 days at 37 DEG C., the chlorio-allantoic membranes removed, homogenized in ice and diluted with the above beef tea and glucose. H.C.C. containing liver and spleen of dogs is homogenized in ice, suspended in water and treated with 35% formaldehyde for one hour. After storage for one week at 4 DEG C., the supernatant liquid is mixed with 2% aqueous sodium bisulphite and excess free formaldehyde is fixed with sodium bisulphite. H.C.C. is also obtained from a tissue culture of dog kidney cells. The mixed vaccine is lyophilised and may be used in admixture with pharmaceutical diluents.
GB2644659A 1958-07-31 1959-07-31 A composite vaccine for the immunization of dogs and foxes against distemper and hepatitis contagiosa canis Expired GB904301A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB49808A DE1076892B (en) 1958-07-31 1958-07-31 Process for the production of a vaccine for the simultaneous immunization of dogs or foxes against distemper and contagious hepatitis

Publications (1)

Publication Number Publication Date
GB904301A true GB904301A (en) 1962-08-29

Family

ID=6968986

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2644659A Expired GB904301A (en) 1958-07-31 1959-07-31 A composite vaccine for the immunization of dogs and foxes against distemper and hepatitis contagiosa canis

Country Status (4)

Country Link
BE (1) BE581259A (en)
CH (1) CH380302A (en)
DE (1) DE1076892B (en)
GB (1) GB904301A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1123105A1 (en) * 1998-09-25 2001-08-16 V.I. Technologies, Inc. Solid phase quenching systems
CN110226520A (en) * 2019-07-25 2019-09-13 西南大学 A kind of method of high-frequency induction Mount Huang herb mixtures tea tissue culture seedling rooting

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH200180A (en) * 1936-03-26 1938-09-30 Frei Walter Dr Prof Process for the manufacture of vaccines.
US2173440A (en) * 1937-04-08 1939-09-19 Salsbury S Lab Dr Treatment of range paralysis
DE1027367B (en) * 1956-08-27 1958-04-03 Allied Lab Inc Process for the production of a mixed vaccine for dogs

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1123105A1 (en) * 1998-09-25 2001-08-16 V.I. Technologies, Inc. Solid phase quenching systems
EP1123105A4 (en) * 1998-09-25 2006-01-04 Vi Technologies Inc Solid phase quenching systems
CN110226520A (en) * 2019-07-25 2019-09-13 西南大学 A kind of method of high-frequency induction Mount Huang herb mixtures tea tissue culture seedling rooting

Also Published As

Publication number Publication date
BE581259A (en) 1960-02-01
CH380302A (en) 1964-07-31
DE1076892B (en) 1960-03-03

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