GB902029A - Process for the manufacture of hydroxy-pregnane compounds - Google Patents

Process for the manufacture of hydroxy-pregnane compounds

Info

Publication number
GB902029A
GB902029A GB3037758A GB3037758A GB902029A GB 902029 A GB902029 A GB 902029A GB 3037758 A GB3037758 A GB 3037758A GB 3037758 A GB3037758 A GB 3037758A GB 902029 A GB902029 A GB 902029A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
manufacture
fluoro
chloro
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3037758A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntax S A
Original Assignee
Syntax S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntax S A filed Critical Syntax S A
Publication of GB902029A publication Critical patent/GB902029A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)

Abstract

16-Hydroxy steroids of the general formula <FORM:0902029/IV (b)/1> and the corresponding 1-dehydro compounds (wherein X is H, Cl, or F and X1 is Cl or F, Y is keto or hydrogen and a b -hydroxyl group) are prepared by incubation (under aerobic conditions) of a culture of Streptomyces roseochromogenus with the corresponding 16-unsubstituted steroid. Examples detail the preparation of 6a -fluoro- and 6a -chloro-16a -nydroxy derivatives of cortisone, hydrocortisone, prednisone and prednisolone together with the 9a -fluoro- and chloro-derivatives. Specifications 834,372, 890,834, 895,340, 902,027 and 902,028 are referred to.
GB3037758A 1957-09-23 1958-09-23 Process for the manufacture of hydroxy-pregnane compounds Expired GB902029A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MX4890057 1957-09-23
MX5188758 1958-08-16

Publications (1)

Publication Number Publication Date
GB902029A true GB902029A (en) 1962-07-25

Family

ID=26640839

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3037758A Expired GB902029A (en) 1957-09-23 1958-09-23 Process for the manufacture of hydroxy-pregnane compounds

Country Status (2)

Country Link
CH (1) CH383370A (en)
GB (1) GB902029A (en)

Also Published As

Publication number Publication date
CH383370A (en) 1964-10-31

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