GB898757A - Production of amides - Google Patents

Production of amides

Info

Publication number
GB898757A
GB898757A GB4343059A GB4343059A GB898757A GB 898757 A GB898757 A GB 898757A GB 4343059 A GB4343059 A GB 4343059A GB 4343059 A GB4343059 A GB 4343059A GB 898757 A GB898757 A GB 898757A
Authority
GB
United Kingdom
Prior art keywords
cyanopyridine
ammonia
aqueous solution
base
column
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4343059A
Inventor
Bertram Yeomans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Distillers Co Yeast Ltd
Distillers Co Ltd
Original Assignee
Distillers Co Yeast Ltd
Distillers Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Distillers Co Yeast Ltd, Distillers Co Ltd filed Critical Distillers Co Yeast Ltd
Priority to GB4343059A priority Critical patent/GB898757A/en
Publication of GB898757A publication Critical patent/GB898757A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

Aliphatic, aromatic and heterocyclic amides involatile in steam are prepared from the corresponding nitriles, which are water-soluble and steam-volatile, by feeding an aqueous solution of the nitrile into an intermediate stage of a distillation column within which water is refluxing, feeding an aqueous solution of a base having a pH greater than 9 into the column or its kettle and removing the amide produced from the base of the column. Specified bases are ammonia, piperidine and hydroxides, and carbonates of the alkali metals. The examples describe the preparation of isonicotinamide from 4-cyanopyridine using (a) ammonium hydroxide, and (b) sodium hydroxide as the base; and 3-cyanopyridine is similarly hydrolysed to nicotinamide. The aqueous solution of cyanopyridine may be supplied as a solution, also comprising picoline and some ammonia, obtained in the production of the cyanopyridine by reaction of the corresponding picoline with ammonia and oxygen. Propionitrile and benzonitrile are also specified starting materials.
GB4343059A 1959-12-22 1959-12-22 Production of amides Expired GB898757A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB4343059A GB898757A (en) 1959-12-22 1959-12-22 Production of amides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4343059A GB898757A (en) 1959-12-22 1959-12-22 Production of amides

Publications (1)

Publication Number Publication Date
GB898757A true GB898757A (en) 1962-06-14

Family

ID=10428718

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4343059A Expired GB898757A (en) 1959-12-22 1959-12-22 Production of amides

Country Status (1)

Country Link
GB (1) GB898757A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2322864A1 (en) * 1975-09-02 1977-04-01 Lummus Co CONTINUOUS PROCESS FOR THE PRODUCTION OF NICOTINAMIDE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2322864A1 (en) * 1975-09-02 1977-04-01 Lummus Co CONTINUOUS PROCESS FOR THE PRODUCTION OF NICOTINAMIDE

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