GB894029A - Process for the purification of 1-dehydro-17ª--methyl-testosterone - Google Patents
Process for the purification of 1-dehydro-17ª--methyl-testosteroneInfo
- Publication number
- GB894029A GB894029A GB41841/60A GB4184160A GB894029A GB 894029 A GB894029 A GB 894029A GB 41841/60 A GB41841/60 A GB 41841/60A GB 4184160 A GB4184160 A GB 4184160A GB 894029 A GB894029 A GB 894029A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dehydro
- compound
- solution
- adsorbent
- testosterone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Selenium impurities contaminating 1-dehydro-17a -methyl-testosterone which has been obtained by dehydrogenating 17a -methyl-testosterone with a selenium compound having a dehydrogenating action are removed by treating the crude 1-dehydro-compound with hydrogen peroxide, separating the resulting acidic fraction from the neutral fraction, treating the neutral fraction with an adsorbent and recovering the purified 1-dehydro-compound from the neutral fraction. Advantageously the crude 1-dehydro-compound, obtained, for example, by a dehydrogenation process using selenium dioxide or selenious acid, is dissolved in a solvent such as acetic acid and treated with a 30% aqueous solution of hydrogen peroxide at room temperature, the product, obtained for example by precipitation with water and filtration, is dissolved in an organic solvent, e.g. toluene or ethyl acetate, and extracted with a aqueous alkaline reagent, such as sodium carbonate, the neutral fraction remaining in solution in the organic solvent is then treated with an adsorbent, such as aluminium oxide, for example by passing the solution through a column of the adsorbent or by adding adsorbent to the solution and filtering off the solid material, and the 1-dehydro compound is then recovered from the solvent by, for example, evaporating the solution and recrystallising the residue. An example is given.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US894029XA | 1959-12-03 | 1959-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB894029A true GB894029A (en) | 1962-04-18 |
Family
ID=22217451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB41841/60A Expired GB894029A (en) | 1959-12-03 | 1960-12-05 | Process for the purification of 1-dehydro-17ª--methyl-testosterone |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB894029A (en) |
-
1960
- 1960-12-05 GB GB41841/60A patent/GB894029A/en not_active Expired
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