GB8912072D0 - Process of preparing 1,2,2,2-tetrafluoroethyl-difluoromethyl ether - Google Patents
Process of preparing 1,2,2,2-tetrafluoroethyl-difluoromethyl etherInfo
- Publication number
- GB8912072D0 GB8912072D0 GB898912072A GB8912072A GB8912072D0 GB 8912072 D0 GB8912072 D0 GB 8912072D0 GB 898912072 A GB898912072 A GB 898912072A GB 8912072 A GB8912072 A GB 8912072A GB 8912072 D0 GB8912072 D0 GB 8912072D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- tetrafluoroethyl
- preparing
- aimed compound
- aimed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/04—Saturated ethers
- C07C43/12—Saturated ethers containing halogen
- C07C43/123—Saturated ethers containing halogen both carbon chains are substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
CF3CHFOCHF2 useful as an anaesthetic is formed by fluorinating CF3CHXOCHF2, wherein X is a halogen atom other than fluorine atom, by an alkali metal fluoride in an aprotic polar solvent in the presence of a phase-transfer catalyst such as tetramethylammonium chloride or 18-crown-6-ether. The reaction proceeds under mild conditions, and the selectivity to the aimed compound is very high. The aimed compound can easily be separated from unreacted starting compound since the boiling point of the starting compound sufficiently differs from that of the aimed compound.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63131453A JPH01301636A (en) | 1988-05-31 | 1988-05-31 | Production of 1,2,2,2-tetrafluoroethyl difluoromethyl ether |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8912072D0 true GB8912072D0 (en) | 1989-07-12 |
GB2219292A GB2219292A (en) | 1989-12-06 |
GB2219292B GB2219292B (en) | 1991-12-11 |
Family
ID=15058313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8912072A Expired - Fee Related GB2219292B (en) | 1988-05-31 | 1989-05-25 | Process of preparing 1,2,2,2-tetrafluoroethyl-difluoromethyl ether |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPH01301636A (en) |
GB (1) | GB2219292B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112142575A (en) * | 2019-06-27 | 2020-12-29 | 鲁南制药集团股份有限公司 | Preparation method of desflurane |
CN113548962A (en) * | 2021-08-13 | 2021-10-26 | 南京信息工程大学 | Recycling treatment method of fluorocarbon residual liquid generated in production of hexafluoroisopropyl methyl ether |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH1036355A (en) * | 1996-07-19 | 1998-02-10 | Ube Ind Ltd | Production of 4-amino-5-chloro-6-(1-fluoroehyl)pyrimidine derivative |
US6800786B1 (en) | 2002-09-25 | 2004-10-05 | Baxter International, Inc. | Preparation of desflurane |
AP2350A (en) | 2004-11-17 | 2012-01-16 | Piramal Critical Care Inc | Method for the preparation of sevoflurane. |
TR200703378T1 (en) * | 2004-11-17 | 2007-08-21 | Minrad Inc.Minrad Inc. | 1,2,2,2-tetrafluoro ethyl difluoro methyl ether production 1,2,2,2-tetrafluoro ethyl difluoro methyl ether production process process |
US9150480B2 (en) | 2005-01-12 | 2015-10-06 | Halocarbon Products Corporation | Synthesis of fluorinated ethers |
CA2597788C (en) * | 2005-02-15 | 2013-07-09 | Halocarbon Products Corporation | Separation/purification of desflurane from hydrogen fluoride |
EP2167453A4 (en) | 2007-07-13 | 2013-03-06 | Piramal Healthcare Ltd | Process for production of 1,2,2,2-tetrafluoroethyl difluoromethyl ether (desflurane) |
GB2587294B (en) * | 2016-02-23 | 2021-06-16 | Sagetech Medical Equipment Ltd | Processes for the preparation of desflurane |
EP3419739A1 (en) | 2016-02-23 | 2019-01-02 | Sagetech Medical Equipment Limited | Improvements to the manufacture and remanufacture of volatile anaesthetic agents using supercritical fluids |
JP7032639B2 (en) | 2017-12-22 | 2022-03-09 | セントラル硝子株式会社 | Purification method and production method of difluoromethyl-1,2,2,2-tetrafluoroethyl ether |
-
1988
- 1988-05-31 JP JP63131453A patent/JPH01301636A/en active Pending
-
1989
- 1989-05-25 GB GB8912072A patent/GB2219292B/en not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112142575A (en) * | 2019-06-27 | 2020-12-29 | 鲁南制药集团股份有限公司 | Preparation method of desflurane |
CN112142575B (en) * | 2019-06-27 | 2023-02-17 | 鲁南制药集团股份有限公司 | Preparation method of desflurane |
CN113548962A (en) * | 2021-08-13 | 2021-10-26 | 南京信息工程大学 | Recycling treatment method of fluorocarbon residual liquid generated in production of hexafluoroisopropyl methyl ether |
CN113548962B (en) * | 2021-08-13 | 2023-06-30 | 南京信息工程大学 | Resource treatment method for fluorocarbon residual liquid generated in production of hexafluoroisopropyl methyl ether |
Also Published As
Publication number | Publication date |
---|---|
GB2219292B (en) | 1991-12-11 |
GB2219292A (en) | 1989-12-06 |
JPH01301636A (en) | 1989-12-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19950525 |