GB2219292B - Process of preparing 1,2,2,2-tetrafluoroethyl-difluoromethyl ether - Google Patents

Process of preparing 1,2,2,2-tetrafluoroethyl-difluoromethyl ether

Info

Publication number
GB2219292B
GB2219292B GB8912072A GB8912072A GB2219292B GB 2219292 B GB2219292 B GB 2219292B GB 8912072 A GB8912072 A GB 8912072A GB 8912072 A GB8912072 A GB 8912072A GB 2219292 B GB2219292 B GB 2219292B
Authority
GB
United Kingdom
Prior art keywords
compound
tetrafluoroethyl
preparing
aimed compound
aimed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB8912072A
Other versions
GB2219292A (en
GB8912072D0 (en
Inventor
Toshikazu Kawai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Central Glass Co Ltd
Original Assignee
Central Glass Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Central Glass Co Ltd filed Critical Central Glass Co Ltd
Publication of GB8912072D0 publication Critical patent/GB8912072D0/en
Publication of GB2219292A publication Critical patent/GB2219292A/en
Application granted granted Critical
Publication of GB2219292B publication Critical patent/GB2219292B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/12—Saturated ethers containing halogen
    • C07C43/123—Saturated ethers containing halogen both carbon chains are substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

CF3CHFOCHF2 useful as an anaesthetic is formed by fluorinating CF3CHXOCHF2, wherein X is a halogen atom other than fluorine atom, by an alkali metal fluoride in an aprotic polar solvent in the presence of a phase-transfer catalyst such as tetramethylammonium chloride or 18-crown-6-ether. The reaction proceeds under mild conditions, and the selectivity to the aimed compound is very high. The aimed compound can easily be separated from unreacted starting compound since the boiling point of the starting compound sufficiently differs from that of the aimed compound.
GB8912072A 1988-05-31 1989-05-25 Process of preparing 1,2,2,2-tetrafluoroethyl-difluoromethyl ether Expired - Fee Related GB2219292B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63131453A JPH01301636A (en) 1988-05-31 1988-05-31 Production of 1,2,2,2-tetrafluoroethyl difluoromethyl ether

Publications (3)

Publication Number Publication Date
GB8912072D0 GB8912072D0 (en) 1989-07-12
GB2219292A GB2219292A (en) 1989-12-06
GB2219292B true GB2219292B (en) 1991-12-11

Family

ID=15058313

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8912072A Expired - Fee Related GB2219292B (en) 1988-05-31 1989-05-25 Process of preparing 1,2,2,2-tetrafluoroethyl-difluoromethyl ether

Country Status (2)

Country Link
JP (1) JPH01301636A (en)
GB (1) GB2219292B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1036355A (en) * 1996-07-19 1998-02-10 Ube Ind Ltd Production of 4-amino-5-chloro-6-(1-fluoroehyl)pyrimidine derivative
US6800786B1 (en) 2002-09-25 2004-10-05 Baxter International, Inc. Preparation of desflurane
WO2006055749A1 (en) * 2004-11-17 2006-05-26 Minrad Inc. Process for production of 1,2,2,2-tetrafluoro ethyl difluoro methyl ether
CN101065346B (en) 2004-11-17 2012-03-21 皮拉莫危急护理有限公司 Method for the preparation of sevoflurane
KR100934295B1 (en) 2005-01-12 2009-12-29 할로카본 프로덕츠 코포레이션 Synthesis of Fluorinated Ethers
EP1912925B1 (en) * 2005-02-15 2015-05-20 Halocarbon Products Corporation Separation/purification of desflurane from hydrogen fluoride
AR070010A1 (en) 2007-07-13 2010-03-10 Piramal Healthcare Ltd PROCESS FOR THE PRODUCTION OF 1,2,2,2 -ETER TETRAFLUOROETIL DIFLUOROMETILO (DESFLURANO)
JP2019514446A (en) 2016-02-23 2019-06-06 セージテック メディカル イクイップメント リミテッドＳａｇｅｔｅｃｈ Ｍｅｄｉｃａｌ Ｅｑｕｉｐｍｅｎｔ Ｌｉｍｉｔｅｄ Improving the production and regeneration of volatile anesthetics using supercritical fluid
GB2587294B (en) * 2016-02-23 2021-06-16 Sagetech Medical Equipment Ltd Processes for the preparation of desflurane
JP7032639B2 (en) * 2017-12-22 2022-03-09 セントラル硝子株式会社 Purification method and production method of difluoromethyl-1,2,2,2-tetrafluoroethyl ether
CN112142575B (en) * 2019-06-27 2023-02-17 鲁南制药集团股份有限公司 Preparation method of desflurane
CN113548962B (en) * 2021-08-13 2023-06-30 南京信息工程大学 Resource treatment method for fluorocarbon residual liquid generated in production of hexafluoroisopropyl methyl ether

Also Published As

Publication number Publication date
GB2219292A (en) 1989-12-06
GB8912072D0 (en) 1989-07-12
JPH01301636A (en) 1989-12-05

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19950525