GB885570A - Pyridazone compounds - Google Patents

Abstract

The invention comprises compounds of the formula <FORM:0885570/IV (b)/1> (in which R11 represents an aliphatically etherified hydroxyl group, and in which the phenyl groups may be substituted by lower alkoxy, alkyl, or nitro groups or halogen atoms) and their salts. Examples detail the preparation of 1-phenyl-3-methoxy - 5 - N - (b - phenylethyl) - piperazino - pyridazone (6), its 3-ethoxy analogue and their hydrochlorides from the 3-chloro-analogue, and also of the 3-methoxy compound from 1-phenyl-3-methoxy-5-chloropyridazone-(6) and from 1-phenyl-3-methoxy-5-piperazino-pyridazone-(6). 1 - Phenyl - 3 - chloro - 5 - N - (b - phenylethyl) - piperazino-pyridazone-(6) is prepared by refluxing 1-phenyl-3,5-dichloro-pyridazone-(6) with N-(b -phenylethyl)-piperazine in ethanol. Specification 826,640 is referred to.ALSO:Pharmaceutical compositions having an analgesic and antipyretic action and capable of increasing the resistance of animal organisms to bacterial and virus infections comprise pyridazones of the formula <FORM:0885570/VI/1> (in which R11 represents an aliphatically etherified hydroxyl group and in which the phenyl groups may be substituted by lower alkoxy, alkyl or nitro groups or halogen atoms) or salts thereof together with a suitable carrier for enteral, parenteral or topical administration. The preparations may take the form, e.g. of tablets, dragees, salves, solutions, suspensions or emulsions and may incorporate preserving, buffering, wetting and stabilizing agents and other therapeutic agents, e.g. sulphonamides. Specified salts are hydrohalides, sulphates, nitrates, phosphates, thiocyanates, acetates, propionates, oxalates, malonates, tartrates, succinates, malates, methane-, ethane-, hydroxyethane-, benzene- and toluene-sulphonates, and salts with theropeutically-active acids. Specification 826,640 is referred to.