GB884098A - Process for the preparation of new 1:4-benzdioxane derivatives - Google Patents
Process for the preparation of new 1:4-benzdioxane derivativesInfo
- Publication number
- GB884098A GB884098A GB41363/58A GB4136358A GB884098A GB 884098 A GB884098 A GB 884098A GB 41363/58 A GB41363/58 A GB 41363/58A GB 4136358 A GB4136358 A GB 4136358A GB 884098 A GB884098 A GB 884098A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- reacted
- hal
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of the formula <FORM:0884098/IV (b)/1> in which R is hydrogen or a straight or branched chain hydrocarbon residue having from 1-4 carbon atoms, R1 is an alkyl residue, Y an oxygen or sulphur atom, n the number 3 or 4 and m the number 0 or 1, and acid addition salts thereof and processes for the preparation thereof in which (a) a 2-halogenomethyl-1,4-benzdioxane of the formula <FORM:0884098/IV (b)/2> in which X is chlorine or bromine, is condensed with a primary amine of the formula H2N-(CH2)n-Y-R at temperatures above 70 DEG C. and the resulting compound, if desired, reacted with an acid to form an acid addition salt thereof, (b) a 2-aminomethyl-1,4-benzdioxane of the formula <FORM:0884098/IV (b)/3> is condensed with a halide of the formula Hal-(CH2)n-Y-R in which Hal is a chlorine, bromine or iodine atom, (c) a compound of the formula <FORM:0884098/IV (b)/4> in which R11 represents an alkali metal atom, is reacted with a molar quantity of an alkyl halide Hal-R in which R has the above meaning except hydrogen and Hal is a chlorine, bromine or iodine atom, (d) a compound of the formula <FORM:0884098/IV (b)/5> is reacted with an alkali metal compound of the formula Me-Y-R in which Me is an alkali metal atom, and the resultant compound, if desired, is reacted with an acid to form an acid addition salt thereof and (e) a compound of the formula <FORM:0884098/IV (b)/6> in which R11 represents a hydrogen atom, is alkylated, the resultant compound being, if desired, converted into an acid addition salt. Detailed examples are given.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE884098X | 1957-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB884098A true GB884098A (en) | 1961-12-06 |
Family
ID=6832285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB41363/58A Expired GB884098A (en) | 1957-12-21 | 1958-12-22 | Process for the preparation of new 1:4-benzdioxane derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB884098A (en) |
-
1958
- 1958-12-22 GB GB41363/58A patent/GB884098A/en not_active Expired
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