GB881855A - Elution of organic substances from ion-exchange resins - Google Patents
Elution of organic substances from ion-exchange resinsInfo
- Publication number
- GB881855A GB881855A GB14985/58A GB1498558A GB881855A GB 881855 A GB881855 A GB 881855A GB 14985/58 A GB14985/58 A GB 14985/58A GB 1498558 A GB1498558 A GB 1498558A GB 881855 A GB881855 A GB 881855A
- Authority
- GB
- United Kingdom
- Prior art keywords
- water
- solvent
- salt
- mixture
- ion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Heparin is recovered from a solution containing it by adsorption upon an ion-exchange resin and elution with a mixture of a watermiscible organic solvent, water and a salt. Typical solvents are methanol, ethanol, isopropanol, ethylene glycol, dioxane, acetone, ethyl acetate and dimethylformamide. A preferred elutrient is a mixture of water, methanol and ammonium chloride. Sufficient water must be present in the solvent to permit ionization of the salt and its proportion may be as low as 1% or as high as 70%.ALSO:A process for the recovery of an ionic organic substance from a solution containing it by adsorbing the substance upon an ion-exchange resin and eluting it from the ion-exchange resin, characterised in that the elutrient is a mixture of a water-miscible organic solvent, water and a salt which is soluble in said solvent-water mixture, the elutrient also being a solvent for the ionic organic substance. The salts must be ionic and may be inorganic or organic, e.g. acetate, propionate, butyrate, benzoate, chloracetate and amine salts. Sufficient water must be present in the solvent to permit ionization of the salt and it may be as low as 1% or as high as 70% water. Typical solvents are methanol, ethanol, isopropanol, ethylene glycol, dioxane, acetone, ethyl acetate and dimethylformamide. A preferred elutrient is a mixture of water, methanol and ammonium chloride. The ionic organic substances include both weak and strong organic acids and bases. Specified organic compounds are (a) the antibiotics penicillin, novobiocin, eulicin and cytovirin; (b) the vitamin p B2 phosphate, vitamin K phosphate and vitamin B1; (c) the alkaloids morphine, quinine, yohimbine and resperine; (d) the acids gibberellic acid, desoxycholic acid, folic acid, palmitic acid, nicotinic acid and ascorbic acid.ALSO:Methyl orange is recovered from a solution containing it by absorption upon an ion-exchange resin and elution with a mixture of a water-miscible organic solvent, water, and a salt. Sufficient water must be present in the solvent to permit ionization of the salt and the proportion of water may be 1%-70%. The salt may be that of an organic or inorganic acid. In an example a solution of methyl orange in ammoniacal water is passed through a column containing a strongly basic styrene-divinylbenzene resin or a weakly basic aminated polystyrene resin. The resin is then eluted with a methanol/ammonium chloride aqueous solution.ALSO:Zinc insulin is recovered from an aqueous hydrochloric acid solution thereof by adsorbing it upon an ion exchange resin and eluting it therefrom with a mixture of a water-miscible organic solvent, water and a salt which is soluble in said water solvent mixture. In the example, the zinc insulin is adsorbed upon Dowex 50-XI resin and eluted with an aqueous solution containing 70% ethanol and 3.5% sodium chloride.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66048557A | 1957-05-21 | 1957-05-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB881855A true GB881855A (en) | 1961-11-08 |
Family
ID=24649722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB14985/58A Expired GB881855A (en) | 1957-05-21 | 1958-05-09 | Elution of organic substances from ion-exchange resins |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE567852A (en) |
CH (1) | CH371449A (en) |
DE (1) | DE1085878B (en) |
FR (1) | FR1209143A (en) |
GB (1) | GB881855A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2141728A (en) * | 1983-04-27 | 1985-01-03 | Canon Kk | Purifying aqueous dyestuff solutions from inorganic salts |
GB2146037A (en) * | 1983-07-28 | 1985-04-11 | Canon Kk | Purifying dyestuff solutions by ion-exchange |
GB2173503A (en) * | 1985-04-12 | 1986-10-15 | Berlin Chemie Veb | Purification of insulin |
CN104031038A (en) * | 2014-07-04 | 2014-09-10 | 东北制药集团股份有限公司 | Method for preparing vitamin B1 hydrochloride with thiol thiamine |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2903981A1 (en) * | 1979-02-02 | 1980-08-07 | Hoechst Ag | RECOVERY OF FLUORINATED EMULGATOR ACIDS FROM BASIC ANION EXCHANGERS |
CN111715877B (en) * | 2020-05-22 | 2022-06-03 | 深圳市华科创智技术有限公司 | Method for purifying nano silver wire |
-
0
- BE BE567852D patent/BE567852A/xx unknown
-
1958
- 1958-05-09 GB GB14985/58A patent/GB881855A/en not_active Expired
- 1958-05-10 DE DEM37632A patent/DE1085878B/en active Pending
- 1958-05-16 CH CH5954358A patent/CH371449A/en unknown
- 1958-05-19 FR FR1209143D patent/FR1209143A/en not_active Expired
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2141728A (en) * | 1983-04-27 | 1985-01-03 | Canon Kk | Purifying aqueous dyestuff solutions from inorganic salts |
GB2146037A (en) * | 1983-07-28 | 1985-04-11 | Canon Kk | Purifying dyestuff solutions by ion-exchange |
GB2173503A (en) * | 1985-04-12 | 1986-10-15 | Berlin Chemie Veb | Purification of insulin |
CN104031038A (en) * | 2014-07-04 | 2014-09-10 | 东北制药集团股份有限公司 | Method for preparing vitamin B1 hydrochloride with thiol thiamine |
Also Published As
Publication number | Publication date |
---|---|
FR1209143A (en) | 1960-02-29 |
CH371449A (en) | 1963-08-31 |
DE1085878B (en) | 1960-07-28 |
BE567852A (en) |
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