GB875007A - Hydrazinium salts - Google Patents
Hydrazinium saltsInfo
- Publication number
- GB875007A GB875007A GB904759A GB904759A GB875007A GB 875007 A GB875007 A GB 875007A GB 904759 A GB904759 A GB 904759A GB 904759 A GB904759 A GB 904759A GB 875007 A GB875007 A GB 875007A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- group
- substituted
- groups
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/28—Nitrogen atoms
- C07D295/30—Nitrogen atoms non-acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention comprises compounds of the formula <FORM:0875007/IV (b)/1> (wherein Ar is benzene, pyridine, naphthalene or quinoline; X and Y are affixed to the same ring of Ar and represent hydrogen or chlorine atoms or cyclohexoxy, hydroxy, lower alkoxy, amino, phenyl or lower alkylamino groups; Z is an oxygen atom or an NH group; B is a -CnH2n-, -CnH(2n-1) OH- or -CnH(2n-1) NRR1-group; R is an Ar-CO-Z-CnH2n-group or a lower alkyl radical which may be substituted by one or more OH groups and R1 is a lower alkyl radical which may be substituted by one or more OH groups, or R and R1, together with the adjacent nitrogen atom, form a morpholine, piperidine or pyrrolidine ring which may be substituted by a methyl group; n is an integer from 2 to 6; A is an anion; and the lower alkyl and lower alkoxy groups contain from 1 to 4 carbon atoms) and their preparation, where for example B is a -CnH2ngroup, either by reacting an amino-alcohol or diamine of the formula HZCnH2nNRR1 with chloramine and reacting the product of the formula [HZCnH2nNRR1 NH2]+Clwith the appropriate aryl acid chloride or by reacting chloramine with the appropriate amino-ester or amino-amide, with subsequent replacement, if desired, of the chloride ion in the products by another anion A- by reaction with the compound MA, where M is hydrogen or a metal. Examples are given and an extensive list of anions is provided. These include anions derived from mineral and other inorganic acids, common mono-basic and di-basic organic acids, choline, cation exchange resins, penicillins, aureomycin, tetracycline, amphomycin, sulphanilamide and other sulphonamides, barbiturates, folic acid, cinchophen and 8-hydroxyquinoline. A further list of suitable amino-ester and amino-amide starting materials is also provided. N-(3-morpholinopropyl)-p-anisamide is prepared from 4-(3-aminopropyl)-morpholine and p - anisoyl chloride. U.S.A. Specifications 2,220,929 and 2,710,248 are referred to.ALSO:Pharmaceutical compositions contain, as essential active ingredients, compounds of the formula <FORM:0875007/VI/1> (wherein Ar is benzene, pyridine, naphthalene or quinoline; X and Y are affixed to the same ring of Ar and represent hydrogen or chlorine atoms or cyclohexoxy, hydroxy, lower alkoxy, amino, phenyl or lower alkylamino groups; Z is an oxygen atom or an NH group; B is a -CnH2n-, -CnH(2n - 1)OH- or -CnH(2n - 1) NRR1- group; R is an Ar-CO-Z-CnH2n-group or a lower alkyl radical which may be substituted by one or more OH groups and R1 is a lower alkyl radical which may be substituted by one or more OH groups, or R and R1, together with the adjacent nitrogen atom, form a morpholine, piperidine or pyrrolidine ring which may be substituted by a methyl group; n is an integer from 2 to 6; A is an anion, and the lower alkyl and lower alkoxy groups contain from 1 to 4 carbon atoms. An aqueous solution of 1,1-dimethyl - 1 - (2 - benzoyloxy - 2 - methyl) butylhydrazinium chloride is described. U.S.A. Specifications 2,220,929 and 2,710,248 are referred to.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB904759A GB875007A (en) | 1959-03-16 | 1959-03-16 | Hydrazinium salts |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB904759A GB875007A (en) | 1959-03-16 | 1959-03-16 | Hydrazinium salts |
Publications (1)
Publication Number | Publication Date |
---|---|
GB875007A true GB875007A (en) | 1961-08-16 |
Family
ID=9864372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB904759A Expired GB875007A (en) | 1959-03-16 | 1959-03-16 | Hydrazinium salts |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB875007A (en) |
-
1959
- 1959-03-16 GB GB904759A patent/GB875007A/en not_active Expired
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