GB872316A - Improvements in or relating to steroids - Google Patents
Improvements in or relating to steroidsInfo
- Publication number
- GB872316A GB872316A GB30861/58A GB3086158A GB872316A GB 872316 A GB872316 A GB 872316A GB 30861/58 A GB30861/58 A GB 30861/58A GB 3086158 A GB3086158 A GB 3086158A GB 872316 A GB872316 A GB 872316A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- general formula
- compounds
- spirostan
- acetoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises steroid compounds of the general formulae <FORM:0872316/IV (b)/1> <FORM:0872316/IV (b)/2> and <FORM:0872316/IV (b)/3> wherein R is hydrogen or an acyl radical derived from an aliphatic hydrocarbon carboxylic acid containing less than 7 carbon atoms and R1 is an alkyl radical containing less than 7 carbon atoms, and a process for the preparation of compounds of the second general formula by reacting a compound of the first general formula above with the required alkyl magnesium halide, and a process for the preparation of 3b -acetoxy-6-methyl-5,16-pregnadien-20-one by reacting 3b -acetoxy - 5a ,6a - epoxy - 22a - spirostan with methyl magnesium halide in an aromatic hydrocarbon solvent and then heating the resulting 3b ,5a -dihydroxy - 6b - methyl - 22a - spirostan with acetic anhydride to form 3b -acetoxy-5a -hydroxy-6-methyl-22a -spirostan and then 3b ,26-diacetoxy-6-methyl-5,20(22)-furostadiene and finally treating with chromic acid (this type of process may be used to prepare any of the compounds of the third general formula above using the required 3b -acyloxy-6-alkyl-5,16-pregnadien-20-one as the starting compound). The compounds of the first general formula may be prepared by treating the required sapogenin substituted in the 3-position by the acyloxy group with an organic peroxy acid such as peroxyacetic, peroxyphthalic and peroxybenzoic acids. Detailed examples are given. Specification 872,315 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US872316XA | 1957-09-27 | 1957-09-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB872316A true GB872316A (en) | 1961-07-05 |
Family
ID=22203907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB30861/58A Expired GB872316A (en) | 1957-09-27 | 1958-09-26 | Improvements in or relating to steroids |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB872316A (en) |
-
1958
- 1958-09-26 GB GB30861/58A patent/GB872316A/en not_active Expired
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