GB871483A - New indene derivatives - Google Patents
New indene derivativesInfo
- Publication number
- GB871483A GB871483A GB43393/59A GB4339359A GB871483A GB 871483 A GB871483 A GB 871483A GB 43393/59 A GB43393/59 A GB 43393/59A GB 4339359 A GB4339359 A GB 4339359A GB 871483 A GB871483 A GB 871483A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- acid
- sulphuric acid
- reacting
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises compounds of the general formula: <FORM:0871483/IV (b)/1> (wherein R1 represents a C1-6 alkyl group and R2 a hydrogen or halogen atom or an alkoxy group, attached to each benzene nucleus), and the preparation thereof by reacting a 1,1diphenylethylene of the general formula: <FORM:0871483/IV (b)/2> with an a -ketocarboxylic acid R1-CO-COOH in the presence of sulphuric acid, or (when R1 =CH3) by reacting pyruvic acid with an aromatic compound of the general formula: <FORM:0871483/IV (b)/3> in the presence of sulphuric acid (at room temperature). Diphenylethylenes of the general Formula III above are prepared by reacting pyruvic acid with a compound of the general Formula V above in the presence of an agent such as sulphuric acid or aluminium chloride at a low temperature to form a 2,2-diarylpropionic acid of the general formula: <FORM:0871483/IV (b)/4> and subjecting this to decarboxylation and dehydration with sulphuric acid. Indenes of the general formula: <FORM:0871483/IV (b)/5> can be prepared by decarboxylating the compounds of the general Formula I above, and may be condensed with aminoalkylhalides to give compounds of the general formula: <FORM:0871483/IV (b)/6> (wherein R and R1 represent hydrocarbon groups) having spasmolytic and vasodilatory properties.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR871483X | 1958-12-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB871483A true GB871483A (en) | 1961-06-28 |
Family
ID=9356199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB43393/59A Expired GB871483A (en) | 1958-12-29 | 1959-12-21 | New indene derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB871483A (en) |
-
1959
- 1959-12-21 GB GB43393/59A patent/GB871483A/en not_active Expired
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