GB871483A - New indene derivatives - Google Patents

New indene derivatives

Info

Publication number
GB871483A
GB871483A GB43393/59A GB4339359A GB871483A GB 871483 A GB871483 A GB 871483A GB 43393/59 A GB43393/59 A GB 43393/59A GB 4339359 A GB4339359 A GB 4339359A GB 871483 A GB871483 A GB 871483A
Authority
GB
United Kingdom
Prior art keywords
general formula
acid
sulphuric acid
reacting
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB43393/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Societe des Usines Chimiques Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA, Societe des Usines Chimiques Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of GB871483A publication Critical patent/GB871483A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of the general formula: <FORM:0871483/IV (b)/1> (wherein R1 represents a C1-6 alkyl group and R2 a hydrogen or halogen atom or an alkoxy group, attached to each benzene nucleus), and the preparation thereof by reacting a 1,1diphenylethylene of the general formula: <FORM:0871483/IV (b)/2> with an a -ketocarboxylic acid R1-CO-COOH in the presence of sulphuric acid, or (when R1 =CH3) by reacting pyruvic acid with an aromatic compound of the general formula: <FORM:0871483/IV (b)/3> in the presence of sulphuric acid (at room temperature). Diphenylethylenes of the general Formula III above are prepared by reacting pyruvic acid with a compound of the general Formula V above in the presence of an agent such as sulphuric acid or aluminium chloride at a low temperature to form a 2,2-diarylpropionic acid of the general formula: <FORM:0871483/IV (b)/4> and subjecting this to decarboxylation and dehydration with sulphuric acid. Indenes of the general formula: <FORM:0871483/IV (b)/5> can be prepared by decarboxylating the compounds of the general Formula I above, and may be condensed with aminoalkylhalides to give compounds of the general formula: <FORM:0871483/IV (b)/6> (wherein R and R1 represent hydrocarbon groups) having spasmolytic and vasodilatory properties.
GB43393/59A 1958-12-29 1959-12-21 New indene derivatives Expired GB871483A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR871483X 1958-12-29

Publications (1)

Publication Number Publication Date
GB871483A true GB871483A (en) 1961-06-28

Family

ID=9356199

Family Applications (1)

Application Number Title Priority Date Filing Date
GB43393/59A Expired GB871483A (en) 1958-12-29 1959-12-21 New indene derivatives

Country Status (1)

Country Link
GB (1) GB871483A (en)

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