GB866489A - Improvements in or relating to the preparation of a ús-ª--tocopherol derivative - Google Patents

Improvements in or relating to the preparation of a ús-ª--tocopherol derivative

Info

Publication number
GB866489A
GB866489A GB4440659A GB4440659A GB866489A GB 866489 A GB866489 A GB 866489A GB 4440659 A GB4440659 A GB 4440659A GB 4440659 A GB4440659 A GB 4440659A GB 866489 A GB866489 A GB 866489A
Authority
GB
United Kingdom
Prior art keywords
tocopherol
solvent
light petroleum
hydrogen succinate
molecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4440659A
Inventor
Antony Stephen Howship
Ronald Herbert Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vitamins Ltd
Original Assignee
Vitamins Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitamins Ltd filed Critical Vitamins Ltd
Priority to GB4440659A priority Critical patent/GB866489A/en
Publication of GB866489A publication Critical patent/GB866489A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

d-a -Tocopheryl hydrogen succinate is prepared by reacting together 1 molecular proportion of d-a -tocopherol and from 1 to 3 molecular proportions of succinic anhydride at elevated temperatures in the presence of 0,05 to 0,50 molecular proportions of a tertiary base, acidifying a solution of the reaction product and separating the formed d-a -tocopheryl hydrogen succinate by crystallisation. The term "tertiary base" is defined as a compound which is a liquid nitrogen base boiling above 85 DEG C. and which yields a stable, watersoluble hydrochloride; such bases may be trialkylamines, di-alkyl-anilines, pyridine, alkylated pyridines, quinoline and isoquinoline. The d-a -tocopherol may be chemically pure or in the form of a concentrate containing at least 40% of the vitamin. From 1 to 3 volumes of a solvent such as benzene, toluene, xylene, light petroleum fraction boiling between 80 DEG and 160 DEG C., diisopropyl ether and higher aliphatic ethers may be added, and the process conducted at 80 DEG -150 DEG C. After the reaction the mixture is taken up in a solvent, washed with hydrochloric acid and water, evaporated to low bulk and then purified from light petroleum at low temperature. Specification 639,011 is referred to.
GB4440659A 1959-12-31 1959-12-31 Improvements in or relating to the preparation of a ús-ª--tocopherol derivative Expired GB866489A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB4440659A GB866489A (en) 1959-12-31 1959-12-31 Improvements in or relating to the preparation of a ús-ª--tocopherol derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4440659A GB866489A (en) 1959-12-31 1959-12-31 Improvements in or relating to the preparation of a ús-ª--tocopherol derivative

Publications (1)

Publication Number Publication Date
GB866489A true GB866489A (en) 1961-04-26

Family

ID=10433155

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4440659A Expired GB866489A (en) 1959-12-31 1959-12-31 Improvements in or relating to the preparation of a ús-ª--tocopherol derivative

Country Status (1)

Country Link
GB (1) GB866489A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3221029A (en) * 1961-03-07 1965-11-30 Eastman Kodak Co Autogenous, vitamin e active beadlet product and process
DE1278445B (en) * 1962-09-01 1968-09-26 Heyl Kommanditgesellschaft Ges Process for the production of solid, water-soluble salts of tocopherol or axerophthol succinic acid half-ester
US5686632A (en) * 1996-08-14 1997-11-11 Henkel Corporation Method of producing a tocopherol product
US6130343A (en) * 1995-04-26 2000-10-10 Henkel Corporation Method of producing a tocopherol product
US6139872A (en) * 1996-08-14 2000-10-31 Henkel Corporation Method of producing a vitamin product
CN100412071C (en) * 2005-08-22 2008-08-20 华东中药工程集团有限公司 High purity delta-alpha-tocopherol succinic acid monoester preparation method
CN105153101A (en) * 2015-09-09 2015-12-16 浙江伊宝馨生物科技股份有限公司 Preparation method of high-purity d-alpha-succinate
CN114195752A (en) * 2022-01-14 2022-03-18 宁波大红鹰生物工程股份有限公司 Environment-friendly d-alpha-tocopherol succinate refining preparation process

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3221029A (en) * 1961-03-07 1965-11-30 Eastman Kodak Co Autogenous, vitamin e active beadlet product and process
DE1278445B (en) * 1962-09-01 1968-09-26 Heyl Kommanditgesellschaft Ges Process for the production of solid, water-soluble salts of tocopherol or axerophthol succinic acid half-ester
US6130343A (en) * 1995-04-26 2000-10-10 Henkel Corporation Method of producing a tocopherol product
US5686632A (en) * 1996-08-14 1997-11-11 Henkel Corporation Method of producing a tocopherol product
US6139872A (en) * 1996-08-14 2000-10-31 Henkel Corporation Method of producing a vitamin product
CN100412071C (en) * 2005-08-22 2008-08-20 华东中药工程集团有限公司 High purity delta-alpha-tocopherol succinic acid monoester preparation method
CN105153101A (en) * 2015-09-09 2015-12-16 浙江伊宝馨生物科技股份有限公司 Preparation method of high-purity d-alpha-succinate
CN114195752A (en) * 2022-01-14 2022-03-18 宁波大红鹰生物工程股份有限公司 Environment-friendly d-alpha-tocopherol succinate refining preparation process

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