GB861980A - Amino aralkyl nitriles - Google Patents

Abstract

Aminoaralkylnitriles of the general formula <FORM:0861980/IV (b)/1> wherein -N=X is a primary, secondary, tertiary or cyclic amino radical, Ar is an unsubstituted or substituted phenyl radical, and R1 is an alkyl, aralkyl or alicyclic radical, are produced by reacting an aminoketone of the general formula R1-CO-CH2-CH2-N=X with hydrogen cyanide, then reacting the hydroxy-nitrile so obtained with a halogenating agent in order to replace the -OH group by a halogen atom, and finally reacting the halogen compound with benzene or a substituted benzene in the presence of aluminium chloride or a similar catalyst. In Example 1, dimethylaminoethyl cetyl ketone hydrochloride is reacted (in solution) with potassium cyanide, and the hydroxynitrile so obtained is treated with thionyl chloride giving a crystalline chloronitrile. The latter is reacted with benzene, using aluminium chloride as catalyst, to yield a - dimethylaminoethyl - a - cetyl - benzyl cyanide. The hydrochloride of this base is also prepared. In Example 2, a -phenyl-a -(4-chloroethyl - 1 - ethyl - piperazino) b - methyl - valeric acid nitrile is obtained starting from sec.-butyl-(4 - chloroethyl - 1 - ethyl - piperazino) - ketone. The products of these examples are claimed per se, and have a variety of pharmacological properties.