GB860633A - Production of penicillin - Google Patents

Production of penicillin

Info

Publication number
GB860633A
GB860633A GB36780/58A GB3678058A GB860633A GB 860633 A GB860633 A GB 860633A GB 36780/58 A GB36780/58 A GB 36780/58A GB 3678058 A GB3678058 A GB 3678058A GB 860633 A GB860633 A GB 860633A
Authority
GB
United Kingdom
Prior art keywords
penicillin
water
sodium
salts
nutrient medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB36780/58A
Inventor
Merlin H Peterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Priority to GB36780/58A priority Critical patent/GB860633A/en
Publication of GB860633A publication Critical patent/GB860633A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Penicillin is produced in increased yield by culturing a penicillin-producing mould, e.g. P. notatum or P. chrysogenum in a nutrient medium under deep culture conditions, characterized in that the nutrient medium contains a water-soluble salt of a polythionic acid in concentrations sufficient to produce this increased yield but insufficient to inhibit fermentation. The polythionic acids are dithionic, trithionic, tetrathionic and pentathionic acids which are used in the form of their water-soluble salts, e.g. sodium, potassium, magnesium and sodium salts. Sodium tetrathionate is used in quantities of 0.025 to 0.6 and preferably 0.1%. The polythionate is added to the nutrient medium prior to sterilization and inoculation. The medium contains water, nutrient salts, a carbohydrate such as lactose, corn steep solids and a precursor such as phenylacetic acid, phenylacetamide and beta phenylethylamine. Specification 730,185 is referred to.
GB36780/58A 1958-11-14 1958-11-14 Production of penicillin Expired GB860633A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB36780/58A GB860633A (en) 1958-11-14 1958-11-14 Production of penicillin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB36780/58A GB860633A (en) 1958-11-14 1958-11-14 Production of penicillin

Publications (1)

Publication Number Publication Date
GB860633A true GB860633A (en) 1961-02-08

Family

ID=10391130

Family Applications (1)

Application Number Title Priority Date Filing Date
GB36780/58A Expired GB860633A (en) 1958-11-14 1958-11-14 Production of penicillin

Country Status (1)

Country Link
GB (1) GB860633A (en)

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