GB849787A - Vitamin a compositions - Google Patents

Vitamin a compositions

Info

Publication number
GB849787A
GB849787A GB14987/58A GB1498758A GB849787A GB 849787 A GB849787 A GB 849787A GB 14987/58 A GB14987/58 A GB 14987/58A GB 1498758 A GB1498758 A GB 1498758A GB 849787 A GB849787 A GB 849787A
Authority
GB
United Kingdom
Prior art keywords
vitamin
casein
formaldehyde
added
palmitate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB14987/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB849787A publication Critical patent/GB849787A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A vitamin A composition comprises an ester of vitamin A uniformly dispersed throughout the reaction product of formaldehyde and partially hydrolysed casein. The acetate, tertiary butyl acetate, pivalate, anthraquinone-b -carboxylate and hemi-succinate, and palmitate esters may be used, the palmitate being preferred. About 5 to 25% by weight of vitamin A of antioxidants may be added, e.g. butylated hydroxy toluene, butylated hydroxy anisole, ascorbyl palmitate, a -tocopherol. About 5 to 15% of amines for example cyclohexylamine, N-ethyl-piperidine, dibutylamine may also be added. The partially hydrolysed casein may be prepared by the mild hydrolysis of casein with dilute mineral acid or proteolytic enzymes such as pepsin or trypsin and may have an a -amino nitrogen content of from less than 1% to 10% (preferably 0,5 to 7,0%). It is conveniently used as an aqueous suspension having a solids content of about 25 to 45% (preferably about 30 to 35%) in which the vitamin A ester and antioxidants are dispersed in amounts which will give a final product having about 10,000 to 500,000 international units of vitamin A activity per gram. Formaldehyde is added with stirring to this mixture preferably at or near room temperature, conveniently as the readily available 37% solution and stirring or mixing is continued for about 5 minutes to an hour (preferably about 15 minutes) during which time the product becomes semi-solid and some granulation may occur. The ratio by weight of formaldehyde to partial hydrolysate of casein may vary from about 1:10 to 1:100 and is preferably 1 part to from 10 to 15 parts of hydrolysate. The reaction mass may be granulated and dried at temperatures up to 100 DEG C. at atmospheric pressure or under vacuum to give a dry, free flowing powder which may be incorporated in animal feed supplements and pharmaceutical preparations.
GB14987/58A 1957-05-24 1958-05-09 Vitamin a compositions Expired GB849787A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US849787XA 1957-05-24 1957-05-24

Publications (1)

Publication Number Publication Date
GB849787A true GB849787A (en) 1960-09-28

Family

ID=22188409

Family Applications (1)

Application Number Title Priority Date Filing Date
GB14987/58A Expired GB849787A (en) 1957-05-24 1958-05-09 Vitamin a compositions

Country Status (1)

Country Link
GB (1) GB849787A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005013708A1 (en) * 2003-07-15 2005-02-17 Dsm Ip Assets B.V. Powderous formulations of fat-soluble active ingredients

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005013708A1 (en) * 2003-07-15 2005-02-17 Dsm Ip Assets B.V. Powderous formulations of fat-soluble active ingredients
JP2007527862A (en) * 2003-07-15 2007-10-04 ディーエスエム アイピー アセッツ ビー.ブイ. Powdered formulation of fat-soluble active ingredients

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