GB845500A - Novel acetophenone and iú¾ú´quinoline derivatives and a process for the manufacture thereof - Google Patents
Novel acetophenone and iú¾ú´quinoline derivatives and a process for the manufacture thereofInfo
- Publication number
- GB845500A GB845500A GB4211/59A GB421159A GB845500A GB 845500 A GB845500 A GB 845500A GB 4211/59 A GB4211/59 A GB 4211/59A GB 421159 A GB421159 A GB 421159A GB 845500 A GB845500 A GB 845500A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acetamido
- ethyl
- dimethoxy
- formula
- methylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises compounds of the formula: <FORM:0845500/IV(b)/1> where R1, R2 and R3 are alkyl or alkoxy groups (any adjacent pair of which alkoxy groups may be combined as alkylenedioxy) and R4 is an alkyl group and where the broken lines denote that the group attached is optional. The compounds may be prepared by acylating an isoquinoline compound of the formula: <FORM:0845500/IV(b)/2> to give the 1-methylene derivative of the formula: <FORM:0845500/IV(b)/3> which is then treated with a dilute mineral acid to open the nitrogen containing ring. The acylation may be carried out by means of an acid anhydride e.g. acetic, propionic or benzoic anhydride and the 1-methylene intermediate need not be isolated. Examples describe the preparation of (1) 2-(b -acetamido-ethyl)-4,5-dimethoxy, (2) 2-(b -propionylamido-ethyl)-4,5-dimethoxy, (3) 2-(b -benzamido-ethyl)-4,5-dimethoxy, (4)2-(b -acetamido-propyl)-4,5-dimethoxy, (5) 2-(b -acetamido-propyl)-4,5-dimethyl, (6) 2-(b -acetamido-ethyl)-4-methoxy, (7) 2-(b -acetamidoethyl)-4,5-methylenedioxy, and (8) 2-(b -acetamido-ethyl)-4,5,6-trimethoxy acetophenone. The preparation of the methylene intermediates is also described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH845500X | 1958-02-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB845500A true GB845500A (en) | 1960-08-24 |
Family
ID=4541776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4211/59A Expired GB845500A (en) | 1958-02-14 | 1959-02-06 | Novel acetophenone and iú¾ú´quinoline derivatives and a process for the manufacture thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB845500A (en) |
-
1959
- 1959-02-06 GB GB4211/59A patent/GB845500A/en not_active Expired
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