GB835842A - New biologically active compounds from oleaceae and process for the preparation thereof - Google Patents

New biologically active compounds from oleaceae and process for the preparation thereof

Info

Publication number
GB835842A
GB835842A GB7424/58A GB742458A GB835842A GB 835842 A GB835842 A GB 835842A GB 7424/58 A GB7424/58 A GB 7424/58A GB 742458 A GB742458 A GB 742458A GB 835842 A GB835842 A GB 835842A
Authority
GB
United Kingdom
Prior art keywords
elenolic acid
acid
elenolic
organic solvent
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7424/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Laboratories Ltd
Original Assignee
Organon Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Laboratories Ltd filed Critical Organon Laboratories Ltd
Publication of GB835842A publication Critical patent/GB835842A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises salts of elenolic acid of general formula (C11H13O6)nM, where M i sodium, potassium, ammonium, calcium, magnesium, zinc or ferrous iron and n is the valency of M; ethers of elenolic acid and its esters of general formula C11H13O6R and C11H12O6(R)2 respectively, where R is an alkyl group of less than six carbon atoms; and a process for the preparation of elenolic acid concentrates by extracting parts of plants of the Oleaceae family with a water-immiscible organic solvent, separating the neutral constituents from the extract by evaporation to dryness, solution of the residue in an aqueous bicarbonate solution of pH 7-7.5, and solvent extraction, whereafter the elenolic acid portion is isolated by acidification of the aqueous phase and extraction with a water-immiscible solvent, e.g. chloroform or ether. Detailed examples illustrate the extraction of elenolic acid from Olea europea and the preparation of its salts, elenolide, and the methyl and ethyl ethers of elenolic acid and its methyl and ethyl esters.ALSO:Concentrates of elenolic acid, C11H14O6 are prepared by extracting parts of plants of the Oleaceae family with a non-water miscible organic solvent, removing the neutral constituents from the extract by evaporating it to dryness, treating an aqueous solution of the residue with bicarbonate (to pH 7-7.5) adding a water-soluble salt, and extracting with a non-water miscible organic solvent, then acidifying the aqueous phase and extracting the elenolic acid with a non-water miscible organic solvent, e.g. chloroform or ether. Elenolic acid, its salts, e.g. magnesium, calcium, zinc, ferrous, ammonium sodium and potassium, elenolide, and acetals and acetalesters of elenolic acid are hypotensive agents which may be administered orally, as suspensions or solutions but preferably in solid form coated against the action of gastric acid, parenterally as an aqueous solution suitable for injection, or by incorporation in suppositories.
GB7424/58A 1957-04-13 1958-03-07 New biologically active compounds from oleaceae and process for the preparation thereof Expired GB835842A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL835842X 1957-04-13

Publications (1)

Publication Number Publication Date
GB835842A true GB835842A (en) 1960-05-25

Family

ID=19843135

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7424/58A Expired GB835842A (en) 1957-04-13 1958-03-07 New biologically active compounds from oleaceae and process for the preparation thereof

Country Status (1)

Country Link
GB (1) GB835842A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081341A2 (en) * 1969-12-11 1971-12-03 Upjohn Co Elenolic acid derivs as antivirals
EP1588710A1 (en) * 2004-04-06 2005-10-26 Shinto Fine Co., Ltd. Anti-allergic composition and method for denaturing allergens

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081341A2 (en) * 1969-12-11 1971-12-03 Upjohn Co Elenolic acid derivs as antivirals
EP1588710A1 (en) * 2004-04-06 2005-10-26 Shinto Fine Co., Ltd. Anti-allergic composition and method for denaturing allergens

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