GB829889A - Esterification of pyridine carboxylic acids - Google Patents

Esterification of pyridine carboxylic acids

Info

Publication number
GB829889A
GB829889A GB34525/57A GB3452557A GB829889A GB 829889 A GB829889 A GB 829889A GB 34525/57 A GB34525/57 A GB 34525/57A GB 3452557 A GB3452557 A GB 3452557A GB 829889 A GB829889 A GB 829889A
Authority
GB
United Kingdom
Prior art keywords
pyridine carboxylic
carboxylic acid
water
carboxylic acids
inert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34525/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of GB829889A publication Critical patent/GB829889A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

Esters of pyridine carboxylic acids are prepared by reacting a pyridine carboxylic acid with an aliphatic alcohol containing at least four carbon atoms under reflux in the presence of an inert, water-immiscible organic solvent capable of forming a constant-boiling azeotrope with water and a C1-3 alkyl sulphonic acid catalyst, said catalyst being present in an amount of up to 20% by weight of the pyridine carboxylic acid, while continuously removing the water formed in the reaction by azeotropic distillation, continuing the reaction until substantially no free pyridine carboxylic acid remains, distilling the inert, water-immiscible organic solvent and unreacted aliphatic alcohol from the reaction mixture, and recovering the pyridine carboxylic acid ester from the residue.
GB34525/57A 1956-11-05 1957-11-05 Esterification of pyridine carboxylic acids Expired GB829889A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US829889XA 1956-11-05 1956-11-05

Publications (1)

Publication Number Publication Date
GB829889A true GB829889A (en) 1960-03-09

Family

ID=22174718

Family Applications (1)

Application Number Title Priority Date Filing Date
GB34525/57A Expired GB829889A (en) 1956-11-05 1957-11-05 Esterification of pyridine carboxylic acids

Country Status (1)

Country Link
GB (1) GB829889A (en)

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