GB826367A - Retrocortin derivatives - Google Patents
Retrocortin derivativesInfo
- Publication number
- GB826367A GB826367A GB18561/58A GB1856158A GB826367A GB 826367 A GB826367 A GB 826367A GB 18561/58 A GB18561/58 A GB 18561/58A GB 1856158 A GB1856158 A GB 1856158A GB 826367 A GB826367 A GB 826367A
- Authority
- GB
- United Kingdom
- Prior art keywords
- retrocortin
- desoxy
- derivatives
- iodide
- hydroretrocortin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises retrocortin derivatives of the general formula <FORM:0826367/IV (b)/1> wherein R is a keto or b -hydroxy group, and Y is a hydrogen or halogen atom, and a process for their preparation by reacting a compound of formula <FORM:0826367/IV (b)/2> wherein R* is an organic group, particularly a lower alkyl group containing up to five carbon atoms, with an iodide salt, preferably an alkali metal iodide such as sodium iodide. The reaction is normally effected in a solvent e.g. methanol, ethanol, propanol, methyl butyl ether, ethyl ether, acetone or methyl ethyl ketone, preferably in the range of 25 DEG to 100 DEG C. and is usually complete in from 30 mins. to 2 hours. In examples: (1) retrocortin 21-methane sulphonate sodium iodide and ethanol are refluxed together, filtered, concentrated and water added, when 21-iodo-21-desoxy-retrocortin separates; similarly (2) to (4) are prepared 21-iodo derivatives of 21-desoxy-hydroretrocortin, 9 - fluoro - 21 - desoxy - retrocortin and 9 - fluoro - 21 - desoxy - hydroretrocortin. Specification 826,368 also is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US826367XA | 1955-01-14 | 1955-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB826367A true GB826367A (en) | 1960-01-06 |
Family
ID=22172417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB18561/58A Expired GB826367A (en) | 1955-01-14 | 1955-12-20 | Retrocortin derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB826367A (en) |
-
1955
- 1955-12-20 GB GB18561/58A patent/GB826367A/en not_active Expired
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