ES8400432A1 - Preparation of pyridobenzoxazine derivative - Google Patents
Preparation of pyridobenzoxazine derivativeInfo
- Publication number
- ES8400432A1 ES8400432A1 ES515608A ES515608A ES8400432A1 ES 8400432 A1 ES8400432 A1 ES 8400432A1 ES 515608 A ES515608 A ES 515608A ES 515608 A ES515608 A ES 515608A ES 8400432 A1 ES8400432 A1 ES 8400432A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- reaction
- formula
- solvent
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
PURPOSE:To prepare the titled compound useful as an antibacterial agent, in high yield, purity and efficiency, e.g. by reacting a chelate compound of a pyridobenzoxazine derivative with a piperazine compound in one step. CONSTITUTION:The objective compound of formula III is prepared in one step by reacting the compound of formulaI(R1 is H or lower alkyl X1 and X2 are halogen) with a piperazine compound of formula II (R2 is H or lower alkyl). As an alternative method, it is prepared by decomposing the compound of formula IV obtained as an intermediate by the reaction of the above compounds. The reaction of the compound of formulaIwith the piperazine compound of formula II is carried out in the absence of solvent or in a solvent (e.g. acetone) and in the presence of an acid acceptor (e.g. TEA) usually at <=100 deg.C. When a ketone is used as the reaction solvent, and the reation is carried out at about its boiling point, or a the reaction is carried out in a polar aprotic solvent at <=room temperature for 0.5-5hr, then the compound of formula IV is obtained as the reaction product, and when the reaction is conducted in an aprotic polar solvent such as dimethylsulfoxide at 50-180 deg.C, the objective compound of formula III can be prepared in one step.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14191981A JPS5843977A (en) | 1981-09-09 | 1981-09-09 | Preparation of pyridobenzoxazine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES515608A0 ES515608A0 (en) | 1983-11-01 |
| ES8400432A1 true ES8400432A1 (en) | 1983-11-01 |
Family
ID=15303207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES515608A Expired ES8400432A1 (en) | 1981-09-09 | 1982-09-09 | Preparation of pyridobenzoxazine derivative |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5843977A (en) |
| AR (1) | AR230451A1 (en) |
| DD (1) | DD203719A5 (en) |
| DK (2) | DK158268C (en) |
| ES (1) | ES8400432A1 (en) |
| FI (1) | FI76345C (en) |
| PL (1) | PL130881B1 (en) |
| PT (1) | PT75523B (en) |
| YU (2) | YU43922B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1267413A (en) * | 1984-04-26 | 1990-04-03 | Abbott Laboratories | Quino-benoxazine antibacterial compounds |
| CA1306750C (en) | 1985-12-09 | 1992-08-25 | Istvan Hermecz | Process for the preparation of quinoline carboxylic acide |
| TW208013B (en) * | 1990-03-01 | 1993-06-21 | Daiichi Co Ltd |
-
1981
- 1981-09-09 JP JP14191981A patent/JPS5843977A/en active Granted
-
1982
- 1982-09-01 AR AR29051082A patent/AR230451A1/en active
- 1982-09-01 FI FI823024A patent/FI76345C/en not_active IP Right Cessation
- 1982-09-07 DK DK399782A patent/DK158268C/en not_active IP Right Cessation
- 1982-09-07 YU YU202182A patent/YU43922B/en unknown
- 1982-09-07 PT PT7552382A patent/PT75523B/en unknown
- 1982-09-08 PL PL23817782A patent/PL130881B1/en unknown
- 1982-09-08 DD DD24311682A patent/DD203719A5/en unknown
- 1982-09-09 ES ES515608A patent/ES8400432A1/en not_active Expired
-
1988
- 1988-03-29 DK DK173588A patent/DK173588A/en active IP Right Grant
- 1988-04-14 YU YU74688A patent/YU46542B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5843977A (en) | 1983-03-14 |
| FI823024L (en) | 1983-03-10 |
| DD203719A5 (en) | 1983-11-02 |
| YU74688A (en) | 1989-12-31 |
| FI76345B (en) | 1988-06-30 |
| YU202182A (en) | 1984-12-31 |
| AR230451A1 (en) | 1984-04-30 |
| PT75523B (en) | 1984-12-12 |
| FI76345C (en) | 1988-10-10 |
| DK173588D0 (en) | 1988-03-29 |
| PL238177A1 (en) | 1983-05-09 |
| YU43922B (en) | 1989-12-31 |
| YU46542B (en) | 1993-11-16 |
| FI823024A0 (en) | 1982-09-01 |
| ES515608A0 (en) | 1983-11-01 |
| PT75523A (en) | 1982-10-01 |
| DK158268B (en) | 1990-04-23 |
| JPH0148910B2 (en) | 1989-10-20 |
| DK158268C (en) | 1990-10-15 |
| DK399782A (en) | 1983-03-10 |
| PL130881B1 (en) | 1984-09-29 |
| DK173588A (en) | 1988-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Transfer granted |