GB822741A - Method of extracting products of therapeutic value from the pancreas - Google Patents
Method of extracting products of therapeutic value from the pancreasInfo
- Publication number
- GB822741A GB822741A GB27771/56A GB2777156A GB822741A GB 822741 A GB822741 A GB 822741A GB 27771/56 A GB27771/56 A GB 27771/56A GB 2777156 A GB2777156 A GB 2777156A GB 822741 A GB822741 A GB 822741A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pancreas
- ammonium sulphate
- lipids
- pulp
- treated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
Abstract
Fresh, preferably defatted, pancreas, minced to a pulp, preferably of average grain size 1-2 mm., is treated with ethyl ether alone or mixed with other solvents such as acetone under conditions of controlled stirring, preferably stirring for 10 to 20 minutes followed by standing for 10 to 20 minutes for a period of 3 to 6 hours, the excess liquid removed and the residual magma separated mechanically by centrifuging or a similar process to obtain an ethereal solution of the lipids, pulp and pancreactic juice. The pancreatic juice is treated with ammonium sulphate in a succession of precipitations carried out by introducing 20 g. of ammonium sulphate per litre of pancreatic juice, filtering the precipitate produced, reintroducing 20 g. of ammonium sulphate per litre of filtrate obtained and repeating this operation until saturation, the different precipitates being collected separately. All operations are carried out between 15 DEG and 25 DEG C., preferably between 18 DEG and 22 DEG C. The excess and recovered ethereal solutions may be distilled and the lipids and ether recovered. The precipitates may be dehydrated at a temperature below 50 DEG C., preferably under vacuum, and used in pulverulent form. The process is particularly applicable to the pancreas of pigs.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR822741X | 1955-09-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB822741A true GB822741A (en) | 1959-10-28 |
Family
ID=9281046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB27771/56A Expired GB822741A (en) | 1955-09-15 | 1956-09-11 | Method of extracting products of therapeutic value from the pancreas |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB822741A (en) |
-
1956
- 1956-09-11 GB GB27771/56A patent/GB822741A/en not_active Expired
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