GB822090A - New sulphonyl-ureas and process for their manufacture - Google Patents
New sulphonyl-ureas and process for their manufactureInfo
- Publication number
- GB822090A GB822090A GB16825/57A GB1682557A GB822090A GB 822090 A GB822090 A GB 822090A GB 16825/57 A GB16825/57 A GB 16825/57A GB 1682557 A GB1682557 A GB 1682557A GB 822090 A GB822090 A GB 822090A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cyclohexyl
- methoxypropyl
- methylbutyl
- hydrocarbon radical
- sulphonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention comprises sulphonyl ureas of the general formula R-SO2-NH-CO-NH-R1 wherein R is an aliphatic or cycloaliphatic hydrocarbon radical of 3 to 8 carbon atoms and R1 is a saturated or unsaturated cyclic or open chain aliphatic hydrocarbon radical interrupted by oxygen or sulphur, and salts of these compounds. The compounds are made by known methods for the preparation of sulphonyl ureas and especially by the methods described in the parent Specification. Examples describe the preparation of sulphonyl ureas of the above general formula in which R and R1 respectively have the values: 3-methylbutyl, 3-methoxypropyl; 3-methylbutyl, 3-ethoxypropyl; cyclohexyl, 2-methoxyethyl; cyclohexyl, 3-methoxypropyl; cyclohexyl, tetrahydrofurfuryl; cyclohexylmethyl, 3-methoxypropyl and cyclohexyl, 2-ethylthioethyl. N - (3 - Methyl - butane - (1) - sulphonyl) - carbamic acid methyl ester used as a starting material is made by reaction of 3-methylbutyl sulphonamide and methyl chloroformate in the presence of potassium carbonate. Specification 595,472 [Group IV], also is referred to.ALSO:Antidiabetic preparations for oral administration comprise sulphonamides of the formula R-SO2-NH-CO-NH-R1 wherein R is an aliphatic or cycloaliphatic hydrocarbon radical of 3-8 carbon atoms and R1 is a saturated or unsaturated cyclic or open-chain aliphatic hydrocarbon radical interrupted by oxygen or sulphur or salts thereof with phyisologically tolerable bases in admixture or conjunction with a pharmaceutical carrier. Sulphonamides are specified in which R and R1 respectively are 3-methylbutyl, 3-methoxy-propyl; 3-methylbutyl, 3-ethoxypropyl; cyclohexyl, 2-methoxyethyl; cyclohexyl, 3-methoxypropyl, cyclohexyl, tetrahydrofurfuryl; cyclohexylmethyl, 3-methoxypropyl and cyclohexyl, 2-ethylthioethyl.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE822090X | 1956-05-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB822090A true GB822090A (en) | 1959-10-21 |
Family
ID=6742122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB16825/57A Expired GB822090A (en) | 1956-05-26 | 1957-05-27 | New sulphonyl-ureas and process for their manufacture |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB822090A (en) |
-
1957
- 1957-05-27 GB GB16825/57A patent/GB822090A/en not_active Expired
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